Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 14/20 | 0.80 |
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | JAK3 | P52333 | 1/20 | 0.60 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.49 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | AKT2 | P31751 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | FRK | P42685 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7021167 | 1.00 | LCK (0.80) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7592510 | 0.90 | LCK (0.84) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7023829 | 0.90 | LCK (0.84) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7591189 | 0.89 | LCK (1.00) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7018359 | 0.89 | LCK (1.00) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7021042 | 0.88 | LCK (0.79) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7018301 | 0.88 | LCK (0.79) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7015494 | 0.88 | LCK (0.78) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7020879 | 0.87 | LCK (0.90) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7661825 | 0.87 | LCK (0.77) | LCKJAK2JAK3MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |