Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.47 |
| ▸ | PRNP | P04156 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.44 |
| ▸ | MTOR | P42345 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2520992 | 0.81 | CDK1 (0.56) | CYP2D6CYP3A4CYP1A2CDK1HSD17B10 | |
| SCHEMBL1147600 | 0.77 | KDM4E (0.82) | CYP2D6CYP1A2CDK1HSD17B10KDM4E | |
| SCHEMBL1147663 | 0.77 | KDM4E (0.82) | CYP2D6CYP1A2CDK1HSD17B10KDM4E | |
| SCHEMBL12210462 | 0.76 | KDM4E (0.62) | CYP2D6CYP3A4CYP1A2CDK1HSD17B10 | |
| SCHEMBL16261305 | 0.76 | CDK1 (0.53) | CYP2D6CYP3A4CYP1A2CDK1HSD17B10 | |
| SCHEMBL1147601 | 0.75 | KDM4E (0.84) | CYP2D6CYP1A2CDK1HSD17B10KDM4E | |
| SCHEMBL15061283 | 0.75 | USP2 (0.71) | CYP2D6CYP3A4CYP1A2HSD17B10KDM4E | |
| SCHEMBL15061237 | 0.75 | USP2 (0.71) | CYP2D6CYP3A4CYP1A2HSD17B10KDM4E | |
| SCHEMBL1152794 | 0.75 | USP2 (0.71) | CYP2D6CYP3A4CYP1A2HSD17B10KDM4E | |
| SCHEMBL1147537 | 0.75 | CDK1 (0.80) | CYP2D6CYP1A2CDK1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0617619-B1 | USE OF APP MODULATORS FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF AMYLOIDOSIS | UNIV ROCKEFELLER (US) | 2003-09-10 | — | — | EP | claimed |
| EP-0617619-B1 | USE OF APP MODULATORS FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF AMYLOIDOSIS | UNIV ROCKEFELLER (US) | 2003-09-10 | — | — | EP | disclosed |
| EP-0617619-A1 | USE OF APP MODULATORS FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF AMYLOIDOSIS | THE ROCKEFELLER UNIVERSITY (US) | 1994-10-05 | — | — | EP | disclosed |
| US-5348963-A | Method of screening for modulators of amyloid formation | THE ROCKEFELLER UNIVERSITY (US) | 1994-09-20 | — | — | US | disclosed |
| US-5242932-A | TREATMENT OF AMYLOIDOSIS ASSOCIATED WITH ALZHEIMER DISEASE | THE ROCKEFELLER UNIVERSITY (US) | 1993-09-07 | — | — | US | disclosed |
| WO-1993011762-A1 | USE OF APP MODULATORS FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF AMYLOIDOSIS | THE ROCKEFELLER UNIVERSITY (US) | 1993-06-24 | — | — | WO | disclosed |