Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.58 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.58 |
| ▸ | PPARG | P37231 | 7/20 | 0.51 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.45 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.45 |
| ▸ | PARG | Q86W56 | 2/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | HPD | P32754 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019248 | 0.84 | MMP13 (0.67) | MMP13SLC22A8HDAC1PARGHPD | |
| SCHEMBL6241073 | 0.84 | MMP13 (0.71) | MMP13SLC22A8DPP4HDAC1PARG | |
| SCHEMBL6255038 | 0.83 | PPARG (0.56) | MMP13PPARGHDAC1ALDH1A1 | |
| SCHEMBL14121373 | 0.82 | PPARG (0.74) | PPARG | |
| SCHEMBL7100616 | 0.79 | MMP13 (0.62) | MMP13SLC22A8PPARGHDAC1PARG | |
| SCHEMBL6253605 | 0.79 | MMP13 (0.62) | MMP13SLC22A8HDAC1PARGMAPK8 | |
| SCHEMBL7095893 | 0.78 | MMP13 (0.61) | MMP13SLC22A8PPARGDPP4HDAC1 | |
| SCHEMBL6256249 | 0.78 | MMP13 (0.61) | MMP13SLC22A8PPARGHDAC1PARG | |
| SCHEMBL6238935 | 0.78 | MMP13 (0.61) | MMP13SLC22A8HDAC1PARGHPD | |
| SCHEMBL7019308 | 0.77 | MMP13 (0.59) | MMP13SLC22A8HDAC1PARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368324-A1 | QUINAZOLINES AS MMP-13 INHIBITORS | Warner-Lambert Company LLC (US) | 2003-12-10 | — | — | EP | claimed |
| WO-2002064572-A1 | QUINAZOLINES AS MMP-13 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | claimed |