SCHEMBL7104253

SCHEMBL7104253

CC(=S)C(Cc1ccccc1)C(=O)O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALPI P09923 1/20 0.57
PKM P14618 1/20 0.57
PTGS1 P23219 1/20 0.57
XIAP P98170 1/20 0.57
SLC7A5 Q01650 1/20 0.57
CYP1A2 P05177 1/20 0.55
MDM2 Q00987 1/20 0.55
CPA1 P15085 3/20 0.48
CPA3 P15088 2/20 0.48
FOLH1 Q04609 1/20 0.48
CPB1 P15086 1/20 0.48
CPB2 Q96IY4 1/20 0.48
KDM4E B2RXH2 1/20 0.47
MEN1 O00255 1/20 0.47
POLB P06746 1/20 0.47
MAPT P10636 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
PTPN7 P35236 1/20 0.47
RECQL P46063 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4826233 1.00 ALPI (0.57) ALPIPKMPTGS1XIAPSLC7A5
SCHEMBL27925911 0.85 LDHA (0.49) ALPIPKMPTGS1XIAPSLC7A5
SCHEMBL9833991 0.83 ALPI (0.61) ALPIPKMPTGS1XIAPSLC7A5
SCHEMBL27300438 0.83 ALPI (0.61) ALPIPKMPTGS1XIAPSLC7A5
SCHEMBL1532407 0.83 ALPI (0.61) ALPIPKMPTGS1XIAPSLC7A5
SCHEMBL7349956 0.83 CYP1A2 (0.59) ALPIPKMPTGS1XIAPSLC7A5
SCHEMBL392827 0.83 CYP1A2 (0.70) ALPIPKMPTGS1XIAPSLC7A5
SCHEMBL7274790 0.82 MDM2 (0.53) ALPIPKMPTGS1XIAPSLC7A5
SCHEMBL7274800 0.82 MDM2 (0.53) ALPIPKMPTGS1XIAPSLC7A5
SCHEMBL16344520 0.82 ALPI (0.59) ALPIPKMPTGS1XIAPSLC7A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1639109-A Kinetic resolution of isomers and resolved isomers BRISTOL MYERS SQUIBB CO (US) 2005-07-13 CN claimed
CN-1639109-A Kinetic resolution of isomers and resolved isomers BRISTOL MYERS SQUIBB CO (US) 2005-07-13 CN disclosed
EP-1140818-B1 AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE AVENTIS PHARMA INC (US) 2003-09-10 EP disclosed
US-6329550-B1 FOR THERAPY OF EMPHYSEMA, OSTEOPOROSIS, RHEUMATOID ARTHRITIS AND NEOPLASTIC DISEASES AVENTIS PHARMACEUTICALS INC. 2001-12-11 US disclosed
EP-1140818-A1 AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE Aventis Pharmaceuticals Inc. (US) 2001-10-10 EP disclosed
WO-2000040552-A1 AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE AVENTIS PHARMACEUTICALS INC. (US) 2000-07-13 WO disclosed
CN-1110865-A Amino acid derivatives EISAI CO LTD (JP) 1995-10-25 CN disclosed