Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 9/20 | 0.64 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.64 |
| ▸ | SYK | P43405 | 1/20 | 0.55 |
| ▸ | PAK4 | O96013 | 1/20 | 0.53 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.48 |
| ▸ | MERTK | Q12866 | 4/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31061104 | 0.96 | ADORA3 (0.69) | ADORA3ADORA2AADORA1SYKPAK4 | |
| SCHEMBL21601510 | 0.96 | ADORA3 (0.69) | ADORA3ADORA2AADORA1SYKPAK4 | |
| SCHEMBL21601563 | 0.96 | ADORA3 (0.69) | ADORA3ADORA2AADORA1SYKPAK4 | |
| SCHEMBL21601504 | 0.96 | ADORA3 (0.69) | ADORA3ADORA2AADORA1SYKPAK4 | |
| SCHEMBL4920899 | 0.85 | ADORA3 (0.53) | ADORA3ADORA2AADORA1SYKPAK4 | |
| SCHEMBL7106970 | 0.84 | SYK (0.50) | ADORA3ADORA2AADORA1SYKMEN1 | |
| SCHEMBL13301199 | 0.84 | IRAK4 (0.51) | ADORA3ADORA2AADORA1SYKPAK4 | |
| SCHEMBL13301201 | 0.83 | FLT3 (0.53) | ADORA3ADORA2AADORA1SYKPAK4 | |
| SCHEMBL13301204 | 0.82 | SYK (0.50) | ADORA3ADORA2AADORA1SYKPAK4 | |
| SCHEMBL459413 | 0.82 | IGF1R (0.51) | ADORA3ADORA2AADORA1SYKIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200435-B1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | NOVARTIS AG (CH) | 2003-10-01 | — | — | EP | disclosed |
| US-6589950-B1 | Treatment of inflammatory or obstructive airways disease for respiratory system disorders | NOVARTIS AG (CH) | 2003-07-08 | — | — | US | disclosed |
| EP-1200435-A1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | Novartis AG (CH) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001009134-A1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | NOVARTIS AG (CH) | 2001-02-08 | — | — | WO | disclosed |