Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | XBP1 | P17861 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5092000 | 0.73 | PLK1 (0.39) | JAK2PLK1PIM1PIM2MAPT | |
| SCHEMBL5091979 | 0.73 | PLK1 (0.39) | JAK2PLK1PIM1PIM2CDK5 | |
| SCHEMBL5091970 | 0.70 | PIM1 (0.39) | JAK2PLK1MEN1KMT2APIM1 | |
| SCHEMBL5101136 | 0.69 | DRD4 (0.51) | JAK2MEN1KMT2APIM1PIM2 | |
| SCHEMBL5100147 | 0.68 | POLB (0.48) | MAPTHTTPOLBEIF2AK2 | |
| SCHEMBL5091272 | 0.68 | JAK2 (0.41) | JAK2MEN1KMT2APIM1PIM2 | |
| SCHEMBL7854769 | 0.67 | JAK2 (0.36) | JAK2PLK1MEN1KMT2APIM1 | |
| SCHEMBL5091556 | 0.66 | DYRK1A (0.56) | JAK2MEN1KMT2AMAPTNPC1 | |
| SCHEMBL7104529 | 0.65 | EIF2AK2 (0.40) | JAK2PLK1DYRK1BMKNK1MKNK2 | |
| SCHEMBL5089098 | 0.64 | PIM1 (0.38) | JAK2PLK1MEN1KMT2APIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |