Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 4/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.36 |
| ▸ | BRAF | P15056 | 6/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 2/20 | 0.35 |
| ▸ | VCP | P55072 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5091987 | 0.78 | CXCR4 (0.50) | MKNK1KDRPLK1PTK2AURKB | |
| SCHEMBL5100147 | 0.76 | POLB (0.48) | EIF2AK2 | |
| SCHEMBL5100134 | 0.76 | MKNK1 (0.46) | MKNK1KDRPLK1PTK2AURKB | |
| SCHEMBL5101136 | 0.71 | DRD4 (0.51) | EIF2AK2MKNK1DYRK1BJAK2VCP | |
| SCHEMBL5091979 | 0.69 | PLK1 (0.39) | EIF2AK2MKNK1PLK1DYRK1BBRAF | |
| SCHEMBL5462899 | 0.68 | CDK4 (0.44) | CDK4GSK3BCDK2 | |
| SCHEMBL5091272 | 0.67 | JAK2 (0.41) | EIF2AK2MKNK1CDK4DYRK1BBRAF | |
| SCHEMBL5091970 | 0.67 | PIM1 (0.39) | EIF2AK2MKNK1PLK1DYRK1BBRAF | |
| SCHEMBL7104522 | 0.65 | JAK2 (0.38) | EIF2AK2MKNK1CDK4PLK1DYRK1B | |
| SCHEMBL5091556 | 0.65 | DYRK1A (0.56) | EIF2AK2DYRK1BJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |