Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6730033 | 0.92 | PARG (0.52) | PARGMAPTPIK3CANAMPTALDH1A1 | |
| SCHEMBL6432931 | 0.88 | MMP13 (0.55) | PARGMAPTPIK3CAL3MBTL1ALDH1A1 | |
| SCHEMBL7017013 | 0.88 | PARG (0.52) | PARGMAPTPIK3CAL3MBTL1ALDH1A1 | |
| SCHEMBL27605971 | 0.88 | PARG (0.48) | PARGMAPTPIK3CAL3MBTL1ALDH1A1 | |
| SCHEMBL6735478 | 0.86 | PARG (0.50) | PARGMAPTPIK3CAL3MBTL1ALDH1A1 | |
| SCHEMBL7629854 | 0.84 | PIK3CA (0.48) | PARGMAPTPIK3CAL3MBTL1MAPK1 | |
| SCHEMBL6532934 | 0.83 | PPARG (0.56) | PARGMAPTGAAL3MBTL1ALDH1A1 | |
| SCHEMBL7624464 | 0.82 | MMP13 (0.51) | PARGMAPTKMT2AALDH1A1HDAC1 | |
| SCHEMBL6730256 | 0.82 | MAPT (0.52) | PARGMAPTKMT2AHDAC1RORC | |
| SCHEMBL6463989 | 0.82 | MMP13 (0.55) | PARGMAPTKMT2AALDH1A1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368324-A1 | QUINAZOLINES AS MMP-13 INHIBITORS | Warner-Lambert Company LLC (US) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002064572-A1 | QUINAZOLINES AS MMP-13 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | disclosed |