Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | B3GNT2 | Q9NY97 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6233923 | 0.92 | NAMPT (0.46) | NAMPTGAAKMT2AALDH1A1MAPT | |
| SCHEMBL6432942 | 0.89 | MAPK1 (0.46) | GAAALDH1A1MAPTB3GNT2SMN1; SMN2 | |
| SCHEMBL27605972 | 0.88 | B3GNT2 (0.44) | GAAKMT2AALDH1A1MAPTB3GNT2 | |
| SCHEMBL6232314 | 0.86 | B3GNT2 (0.46) | GAAKMT2AALDH1A1MAPTB3GNT2 | |
| SCHEMBL7629865 | 0.85 | MAPK1 (0.43) | GAAKMT2AALDH1A1MAPTB3GNT2 | |
| SCHEMBL6231298 | 0.83 | RXFP1 (0.50) | GAAKMT2AALDH1A1MAPTB3GNT2 | |
| SCHEMBL6218995 | 0.82 | MEN1 (0.54) | GAAKMT2AALDH1A1MAPTB3GNT2 | |
| SCHEMBL7624469 | 0.82 | MEN1 (0.50) | GAAKMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL7021536 | 0.81 | B3GNT2 (0.45) | NAMPTGAAKMT2AALDH1A1MAPT | |
| SCHEMBL6232952 | 0.80 | MAPT (0.47) | GAAKMT2AALDH1A1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368324-A1 | QUINAZOLINES AS MMP-13 INHIBITORS | Warner-Lambert Company LLC (US) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002064572-A1 | QUINAZOLINES AS MMP-13 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | disclosed |