Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 9/20 | 0.43 |
| ▸ | PGK1 | P00558 | 3/20 | 0.39 |
| ▸ | PGK2 | P07205 | 3/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.38 |
| ▸ | NT5E | P21589 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL7104783 | 0.93 | ADORA2A (0.45) | ADORA2APGK1PGK2ADORA3ADORA1 | |
| SCHEMBL7103493 | 0.92 | ADORA2A (0.47) | ADORA2APGK1PGK2ADORA3ADORA1 | |
| SCHEMBL7104786 | 0.80 | ADORA2A (0.47) | ADORA2APGK1PGK2ADORA3ADORA1 | |
| Formic Acid SCHEMBL6943622 | 0.79 | ADORA2A (0.44) | ADORA2APGK1PGK2ADORA3ADORA1 | |
| SCHEMBL6839818 | 0.78 | ADORA2A (0.46) | ADORA2APGK1PGK2ADORA3ADORA1 | |
| SCHEMBL7223581 | 0.77 | ADORA3 (0.46) | ADORA2AADORA3ADORA1ADORA2BNT5E | |
| SCHEMBL7103630 | 0.77 | ADORA2A (0.46) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL7566399 | 0.76 | ADORA2A (0.41) | ADORA2AADORA1ADORA2B | |
| SCHEMBL7229569 | 0.75 | ADORA3 (0.52) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL7102138 | 0.75 | ADORA2A (0.46) | ADORA2AADORA3ADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090023-B1 | 2-(PURIN-9-YL)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | GLAXO GROUP LTD (GB) | 2003-09-10 | — | — | EP | disclosed |
| EP-1090023-A1 | 2-(PURIN-9-YL)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067264-A1 | 2-(PURIN-9-YL)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-12-29 | — | — | WO | disclosed |