Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4893816 | 0.95 | SMN1; SMN2 (0.59) | SMN1; SMN2KDM4ERAB9ANPC1BRAF | |
| SCHEMBL7107687 | 0.92 | ALK (0.57) | SMN1; SMN2KDM4ERAB9ANPC1TP53 | |
| SCHEMBL4894962 | 0.88 | BRAF (0.54) | SMN1; SMN2KDM4ERAB9ANPC1BRAF | |
| SCHEMBL4898620 | 0.87 | ALK (0.61) | SMN1; SMN2KDM4ERAB9ANPC1TP53 | |
| SCHEMBL4901287 | 0.84 | RAB9A (0.50) | SMN1; SMN2KDM4ERAB9ANPC1BRAF | |
| SCHEMBL4898607 | 0.83 | BRAF (0.61) | SMN1; SMN2KDM4ERAB9ANPC1BRAF | |
| SCHEMBL7108322 | 0.83 | GSK3B (0.50) | SMN1; SMN2RAB9ANPC1BRAFMAPT | |
| SCHEMBL4892691 | 0.81 | ALK (0.55) | SMN1; SMN2KDM4ERAB9ANPC1TP53 | |
| SCHEMBL4889912 | 0.80 | MAPKAPK2 (0.55) | SMN1; SMN2KDM4ERAB9ANPC1BRAF | |
| SCHEMBL4889926 | 0.80 | MAPKAPK2 (0.55) | SMN1; SMN2KDM4ERAB9ANPC1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347975-A1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | Aventis Pharma S.A. (FR) | 2003-10-01 | — | — | EP | claimed |
| WO-2002051843-A1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | AVENTIS PHARMA S.A. (FR) | 2002-07-04 | — | — | WO | claimed |
| EP-1347975-A1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | Aventis Pharma S.A. (FR) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002051843-A1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | AVENTIS PHARMA S.A. (FR) | 2002-07-04 | — | — | WO | disclosed |