Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 10/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 10/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.49 |
| ▸ | NT5E | P21589 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7103371 | 0.90 | ADORA3 (0.56) | ADORA3ADORA2AADORA1ADORA2BNT5E | |
| SCHEMBL6835048 | 0.90 | ADORA3 (0.56) | ADORA3ADORA2AADORA1ADORA2BNT5E | |
| SCHEMBL7106559 | 0.88 | ADORA2A (0.55) | ADORA3ADORA2AADORA1ADORA2BNT5E | |
| SCHEMBL7105088 | 0.87 | ADORA2A (0.50) | ADORA3ADORA2AADORA1ADORA2BNT5E | |
| SCHEMBL7104798 | 0.87 | ADORA2A (0.56) | ADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL8086128 | 0.87 | ADORA3 (0.54) | ADORA3ADORA2AADORA1ADORA2BNT5E | |
| SCHEMBL238290 | 0.86 | ADORA2A (0.65) | ADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL4433192 | 0.86 | ADORA2A (0.65) | ADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL7104916 | 0.85 | ADORA2A (0.53) | ADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL8092227 | 0.85 | ADORA2A (0.52) | ADORA3ADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090023-B1 | 2-(PURIN-9-YL)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | GLAXO GROUP LTD (GB) | 2003-09-10 | — | — | EP | disclosed |
| EP-1090023-A1 | 2-(PURIN-9-YL)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067264-A1 | 2-(PURIN-9-YL)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-12-29 | — | — | WO | disclosed |