Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD5 | P21918 | 4/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8011020 | 1.00 | DRD5 (0.46) | DRD5ACHEMEN1KMT2AKDM1A | |
| Hydrochloric Acid SCHEMBL8074492 | 0.98 | DRD5 (0.48) | DRD5ACHEMEN1KMT2AKDM1A | |
| SCHEMBL1748257 | 0.87 | CHRNA7 (0.48) | ACHECHRNA7CA1CA2 | |
| SCHEMBL15109677 | 0.81 | ACHE (0.40) | ACHEKDM1A | |
| SCHEMBL13131186 | 0.77 | ACHE (0.45) | ACHEMEN1KMT2AKDM4C | |
| SCHEMBL28046681 | 0.76 | CA1 (0.54) | CHRNA7CA1CA2 | |
| SCHEMBL355553 | 0.76 | CA1 (0.54) | CHRNA7CA1CA2 | |
| Hydrochloric Acid SCHEMBL2816232 | 0.76 | ACHE (0.44) | ACHEMEN1KMT2AKDM4C | |
| Hydrochloric Acid SCHEMBL15226690 | 0.76 | ACHE (0.44) | ACHEMEN1KMT2AKDM4C | |
| Hydrochloric Acid SCHEMBL17910635 | 0.75 | CA1 (0.53) | CHRNA7CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968174-B1 | OPTICALLY ACTIVE 2-AMINOTETRALINE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, ACTIVE IN PREVENTING AND TREATING SEPTIC SHOCK | SIGMA TAU IND FARMACEUTI (IT) | 2003-01-22 | — | — | EP | disclosed |
| US-6225501-B1 | S(-)-2-AMINO-6-FLUORO-7-METHOXYTETRALINE | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2001-05-01 | — | — | US | disclosed |
| EP-0968174-A1 | OPTICALLY ACTIVE 2-AMINOTETRALINE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, ACTIVE IN PREVENTING AND TREATING SEPTIC SHOCK | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998033762-A9 | OPTICALLY ACTIVE 2-AMINOTETRALINE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, ACTIVE IN PREVENTING AND TREATING SEPTIC SHOCK | — | 1998-12-30 | — | — | WO | disclosed |
| WO-1998033762-A1 | OPTICALLY ACTIVE 2-AMINOTETRALINE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, ACTIVE IN PREVENTING AND TREATING SEPTIC SHOCK | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1998-08-06 | — | — | WO | disclosed |