Dihydrospingosine

Dihydrospingosine

SCHEMBL7106054

CCCCCCCCCCCCCCC[C@H](O)[C@H](N)CO

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 4/20 1.00
SPHK1 Q9NYA1 4/20 1.00
LMNA P02545 4/20 1.00
MAPT P10636 4/20 1.00
GMNN O75496 3/20 1.00
POLB P06746 3/20 1.00
BLM P54132 3/20 1.00
CETP P11597 3/20 1.00
UBE2N P61088 3/20 1.00
THPO P40225 2/20 1.00
TP53 P04637 2/20 1.00
CYP1A2 P05177 2/20 1.00
MTOR P42345 1/20 1.00
KDM4E B2RXH2 1/20 1.00
CYP3A4 P08684 1/20 1.00
HTT P42858 1/20 1.00
CSNK1E P49674 1/20 0.54
MEN1 O00255 4/20 0.50
KMT2A Q03164 4/20 0.50
GLA P06280 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1907293 1.00 CYP2D6 (1.00) CYP2D6SPHK1LMNAMAPTGMNN
SCHEMBL18127645 1.00 CYP2D6 (1.00) CYP2D6SPHK1LMNAMAPTGMNN
SCHEMBL8746720 1.00 CYP2D6 (1.00) CYP2D6SPHK1LMNAMAPTGMNN
SCHEMBL1901499 1.00 CYP2D6 (1.00) CYP2D6SPHK1LMNAMAPTGMNN
Dihydrospingosine SCHEMBL3509781 1.00 CYP2D6 (1.00) CYP2D6SPHK1LMNAMAPTGMNN
Dihydrospingosine SCHEMBL13285654 1.00 CYP2D6 (1.00) CYP2D6SPHK1LMNAMAPTGMNN
Dihydrospingosine SCHEMBL1905632 1.00 CYP2D6 (1.00) CYP2D6SPHK1LMNAMAPTGMNN
SCHEMBL21660227 1.00 CYP2D6 (1.00) CYP2D6SPHK1LMNAMAPTGMNN
SCHEMBL21431064 1.00 CYP2D6 (1.00) CYP2D6SPHK1LMNAMAPTGMNN
SCHEMBL12330726 1.00 CYP2D6 (1.00) CYP2D6SPHK1LMNAMAPTGMNN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12629421-B2 Artificially synthesized sphingosine derivative lipoid monomer and use of same for delivering nucleic acid BEIJING BAISHIHEKANG PHARMACEUTICAL TECHNOLOGY (BSJPHARMA) CO., LTD (CN) 2026-05-19 US disclosed
US-11974969-B2 Artificially synthesized sphingosine derivative lipoid monomer and use of same for delivering nucleic acid INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES (CN) 2024-05-07 US disclosed
US-20240099993-A1 ARTIFICIALLY SYNTHESIZED SPHINGOSINE DERIVATIVE LIPOID MONOMER AND USE OF SAME FOR DELIVERING NUCLEIC ACID BEIJING BAISHIHEKANG PHARMACEUTICAL TECHNOLOGY (BSJPHARMA) CO., LTD (CN) 2024-03-28 US disclosed
CN-117740961-A Compound analysis method of liquorice and liquorice probiotics fermentation preparation 北京中医药大学 2024-03-22 CN disclosed
US-11298412-B2 Sphingoid compounds for prophylaxis and/or therapy of coronaviridae infection Harbins Ruhr Bioscience, Inc. (US) 2022-04-12 US disclosed
US-20220016222-A1 SPHINGOID COMPOUNDS FOR PROPHYLAXIS AND/OR THERAPY OF CORONAVIRIDAE INFECTION Harbins Ruhr Bioscience, Inc. 2022-01-20 US disclosed
US-20210015767-A1 ARTIFICIALLY SYNTHESIZED SPHINGOSINE DERIVATIVE LIPOID MONOMER AND USE OF SAME FOR DELIVERING NUCLEIC ACID BEIJING BAISHIHEKANG PHARMACEUTICAL TECHNOLOGY (BSJPHARMA) CO., LTD (CN) 2021-01-21 US disclosed
US-20200268686-A1 SPHINGOID COMPOUNDS FOR PROPHYLAXIS AND/OR THERAPY OF A VIRAL INFECTION Harbins Ruhr Bioscience, Inc. 2020-08-27 US disclosed
US-10688065-B2 Sphingoid compounds for prophylaxis and/or therapy of a viral infection Harbins Ruhr Bioscience, Inc. (US) 2020-06-23 US disclosed
US-20200113850-A1 SPHINGOID COMPOUNDS FOR PROPHYLAXIS AND/OR THERAPY OF A VIRAL INFECTION Harbins Ruhr Bioscience, Inc. 2020-04-16 US disclosed
WO-2019185038-A1 ARTIFICIALLY SYNTHESIZED SPHINGOSINE DERIVATIVE LIPOID MONOMER AND USE OF SAME FOR DELIVERING NUCLEIC ACID 中国医学科学院基础医学研究所 2019-10-03 WO disclosed
US-20150258043-A1 USE OF SPHINGOID LONG CHAIN BASES AND THEIR ANALOGS IN TREATING AND PREVENTING BACTERIAL INFECTIONS UNIVERSITY OF DUISBURG-ESSEN (DE) 2015-09-17 US disclosed
US-20150258043-A1 USE OF SPHINGOID LONG CHAIN BASES AND THEIR ANALOGS IN TREATING AND PREVENTING BACTERIAL INFECTIONS UNIVERSITY OF DUISBURG-ESSEN (DE) 2015-09-17 US disclosed
EP-0964673-B1 PROTECTIVE AGENTS FOR SKIN AND HAIR TAKASAGO PERFUMERY CO LTD (JP) 2003-10-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240099993-A1 ARTIFICIALLY SYNTHESIZED SPHINGOSINE DERIVATIVE LIPOID MONOMER AND USE OF SAME FOR DELIVERING NUCLEIC ACID SPHK2, SPHK1, S1PR2 CYP2D6 4037/4885SPHK1 2/4885LMNA 220/4885
US-20200268686-A1 SPHINGOID COMPOUNDS FOR PROPHYLAXIS AND/OR THERAPY OF A VIRAL INFECTION SPHK1, SPHK2, S1PR1 CYP2D6 4449/4885SPHK1 1/4885LMNA 835/4885
US-20220016222-A1 SPHINGOID COMPOUNDS FOR PROPHYLAXIS AND/OR THERAPY OF CORONAVIRIDAE INFECTION SPHK1, SPHK2, S1PR2 CYP2D6 3331/4885SPHK1 1/4885LMNA 1095/4885
US-12629421-B2 Artificially synthesized sphingosine derivative lipoid monomer and use of same for delivering nucleic acid S1PR2, S1PR3, S1PR1 CYP2D6 4264/4885SPHK1 8/4885LMNA 77/4885
US-20210015767-A1 ARTIFICIALLY SYNTHESIZED SPHINGOSINE DERIVATIVE LIPOID MONOMER AND USE OF SAME FOR DELIVERING NUCLEIC ACID SPHK2, SPHK1, S1PR2 CYP2D6 4037/4885SPHK1 2/4885LMNA 220/4885
US-10688065-B2 Sphingoid compounds for prophylaxis and/or therapy of a viral infection SPHK1, SPHK2, S1PR1 CYP2D6 4449/4885SPHK1 1/4885LMNA 835/4885
US-20200113850-A1 SPHINGOID COMPOUNDS FOR PROPHYLAXIS AND/OR THERAPY OF A VIRAL INFECTION SPHK1, SPHK2, S1PR1 CYP2D6 4449/4885SPHK1 1/4885LMNA 835/4885
US-20150258043-A1 USE OF SPHINGOID LONG CHAIN BASES AND THEIR ANALOGS IN TREATING AND PREVENTING BACTERIAL INFECTIONS SPTSSB, CFTR, SGMS1 CYP2D6 4554/4885SPHK1 9/4885LMNA 1458/4885
US-11298412-B2 Sphingoid compounds for prophylaxis and/or therapy of coronaviridae infection SPHK1, SPHK2, S1PR2 CYP2D6 3331/4885SPHK1 1/4885LMNA 1095/4885
US-11974969-B2 Artificially synthesized sphingosine derivative lipoid monomer and use of same for delivering nucleic acid SPHK2, SPHK1, S1PR2 CYP2D6 4037/4885SPHK1 2/4885LMNA 220/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.