Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.65 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.64 |
| ▸ | CDC25B | P30305 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | APAF1 | O14727 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 2/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | GALK1 | P51570 | 1/20 | 0.50 |
| ▸ | UBE2I | P63279 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9541047 | 0.87 | LOXL2 (0.57) | PARP1LOXL2CDC25BKMT2AKDM4E | |
| SCHEMBL31717057 | 0.87 | LOXL2 (0.57) | PARP1LOXL2CDC25BKMT2AKDM4E | |
| SCHEMBL5214046 | 0.87 | LOXL2 (0.57) | PARP1LOXL2CDC25BKMT2AKDM4E | |
| SCHEMBL31716561 | 0.87 | LOXL2 (0.57) | PARP1LOXL2CDC25BKMT2AKDM4E | |
| SCHEMBL6602290 | 0.84 | LOXL2 (0.54) | PARP1LOXL2CDC25BKMT2AKDM4E | |
| SCHEMBL6603861 | 0.84 | LOXL2 (0.62) | PARP1LOXL2CDC25BKMT2AKDM4E | |
| SCHEMBL31717068 | 0.83 | LOXL2 (0.53) | PARP1LOXL2CDC25BKMT2AKDM4E | |
| SCHEMBL5222703 | 0.83 | CDC25B (0.58) | PARP1LOXL2CDC25BKMT2AKDM4E | |
| SCHEMBL6600286 | 0.81 | LOXL2 (0.50) | PARP1LOXL2CDC25BKMT2AAPAF1 | |
| SCHEMBL7452968 | 0.78 | LOXL2 (0.68) | PARP1LOXL2CDC25BKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110724101-A | Polysubstituted isoquinoline-1 (2H) -ketone derivative and preparation method thereof | 成都大学 | 2020-01-24 | — | — | CN | disclosed |
| US-6664269-B2 | Adminisetring isoquinolinone compounds for therapy of disease mediated by the enzyme poly(ADP- ribose)polymerase (\"PARP\") | MAYBRIDGE PLC (GB) | 2003-12-16 | — | — | US | disclosed |
| US-20030008896-A1 | Isoquinolinone derivatives | KUDOS PHARMACEUTICALS LIMITED (GB) | 2003-01-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030008896-A1 | Isoquinolinone derivatives | PARP1, PARP2, PARP3 | PARP1 1/4885LOXL2 3607/4885CDC25B 2765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.