Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | DNM1 | Q05193 | 7/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.40 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL331221 | 1.00 | HTT (0.47) | HTTDNM1EPHX1PLA2G1BHSP90AA1 | |
| Hydrochloric Acid SCHEMBL1977630 | 1.00 | HTT (0.47) | HTTDNM1EPHX1PLA2G1BHSP90AA1 | |
| Hydrochloric Acid SCHEMBL3039065 | 1.00 | HTT (0.47) | HTTDNM1EPHX1PLA2G1BHSP90AA1 | |
| Hydrochloric Acid SCHEMBL7926574 | 1.00 | HTT (0.47) | HTTDNM1EPHX1PLA2G1BHSP90AA1 | |
| Hydrochloric Acid SCHEMBL18426217 | 1.00 | HTT (0.47) | HTTDNM1EPHX1PLA2G1BHSP90AA1 | |
| Hydrochloric Acid SCHEMBL10383927 | 1.00 | HTT (0.47) | HTTDNM1EPHX1PLA2G1BHSP90AA1 | |
| SCHEMBL13766065 | 0.98 | HTT (0.48) | HTTDNM1EPHX1KMT2AZDHHC20 | |
| SCHEMBL16798891 | 0.98 | HTT (0.48) | HTTDNM1EPHX1KMT2AZDHHC20 | |
| SCHEMBL5713236 | 0.98 | HTT (0.48) | HTTDNM1EPHX1KMT2AZDHHC20 | |
| SCHEMBL16799240 | 0.98 | HTT (0.48) | HTTDNM1EPHX1KMT2AZDHHC20 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0859547-B1 | VIRUS INACTIVATING COATINGS | SURMODICS INC (US) | 2003-09-17 | — | — | EP | disclosed |
| EP-0859547-A4 | VIRUS INACTIVATING COATINGS | SURMODICS INC (US) | 2000-12-20 | — | — | EP | disclosed |
| EP-0859547-A1 | VIRUS INACTIVATING COATINGS | BSI Corporation (US) | 1998-08-26 | — | — | EP | disclosed |
| WO-1996039821-A1 | VIRUS INACTIVATING COATINGS | BSI CORPORATION (US) | 1996-12-19 | — | — | WO | disclosed |