Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 14/20 | 0.73 |
| ▸ | PLG | P00747 | 6/20 | 0.73 |
| ▸ | F10 | P00742 | 3/20 | 0.73 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.73 |
| ▸ | PLAT | P00750 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7102702 | 0.86 | F2 (0.60) | F2PLGF10PRSS1 | |
| SCHEMBL27414923 | 0.85 | F2 (0.59) | F2PLGF10PRSS1OPRM1 | |
| Sulfuric Acid SCHEMBL7264620 | 0.77 | F2 (0.54) | F2PLGOPRM1 | |
| SCHEMBL7393620 | 0.77 | PLG (0.53) | F2PLGF10PRSS1PLAT | |
| Hydrochloric Acid SCHEMBL7399028 | 0.76 | PLG (0.53) | F2PLGF10PRSS1PLAT | |
| Hydrochloric Acid SCHEMBL7294997 | 0.76 | F2 (0.53) | F2PLGF10PRSS1PLAT | |
| SCHEMBL7391431 | 0.76 | PLG (0.55) | F2PLGF10PRSS1PLAT | |
| Hydrochloric Acid SCHEMBL7395370 | 0.76 | PLG (0.54) | F2PLGF10PRSS1PLAT | |
| Efegatran SCHEMBL7273879 | 0.76 | F2 (0.56) | F2PLGF10PRSS1OPRM1 | |
| Efegatran SCHEMBL564291 | 0.76 | F2 (0.56) | F2PLGF10PRSS1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0479489-B1 | Tripeptide antithrombotic agents | LILLY CO ELI (US) | 2003-03-19 | — | — | EP | disclosed |
| EP-0837071-A1 | Tripeptide antithrombotic agents | ELI LILLY AND COMPANY (US) | 1998-04-22 | — | — | EP | disclosed |
| EP-0685489-A2 | Tripeptide antithrombotic agents | ELI LILLY AND COMPANY (US) | 1995-12-06 | — | — | EP | disclosed |
| EP-0684258-A2 | Tripeptide antithrombotic agents | ELI LILLY AND COMPANY (US) | 1995-11-29 | — | — | EP | disclosed |
| US-5430023-A | Tripeptide antithrombotic agents | ELI LILLY AND COMPANY (US) | 1995-07-04 | — | — | US | disclosed |
| EP-0479489-A2 | Tripeptide antithrombotic agents | ELI LILLY AND COMPANY (US) | 1992-04-08 | — | — | EP | disclosed |