Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 20/20 | 0.69 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | GLP1R | P43220 | 1/20 | 0.51 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.51 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7105737 | 0.82 | CCR2 (0.48) | CCR2ADRB2HRH1DRD3GLP1R | |
| SCHEMBL3897497 | 0.82 | CCR2 (1.00) | CCR2ADRB2HRH1DRD3GLP1R | |
| SCHEMBL3897496 | 0.82 | CCR2 (1.00) | CCR2ADRB2HRH1DRD3GLP1R | |
| SCHEMBL7148191 | 0.81 | CCR2 (0.71) | CCR2ADRB2HRH1DRD3GLP1R | |
| SCHEMBL4850015 | 0.81 | CCR2 (0.62) | CCR2ADRB2HRH1DRD3GLP1R | |
| SCHEMBL4850026 | 0.81 | CCR2 (0.62) | CCR2ADRB2HRH1DRD3GLP1R | |
| SCHEMBL3894943 | 0.81 | CCR2 (0.78) | CCR2ADRB2HRH1DRD3GLP1R | |
| SCHEMBL3894948 | 0.81 | CCR2 (0.78) | CCR2ADRB2HRH1DRD3GLP1R | |
| SCHEMBL3887381 | 0.80 | CCR2 (0.72) | CCR2ADRB2HRH1DRD3GLP1R | |
| SCHEMBL3887388 | 0.80 | CCR2 (0.72) | CCR2ADRB2HRH1DRD3GLP1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343751-A2 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002060859-A2 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-08-08 | — | — | WO | disclosed |