Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | ATP4A | P20648 | 2/20 | 0.34 |
| ▸ | ATP4B | P51164 | 2/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.30 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.30 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6529295 | 1.00 | ELANE (0.35) | ELANEATP4AATP4BKIF11HCRTR1 | |
| SCHEMBL5037175 | 1.00 | ELANE (0.35) | ELANEATP4AATP4BKIF11HCRTR1 | |
| SCHEMBL5746631 | 0.84 | ELANE (0.34) | ELANEATP4AATP4BCYP3A4CYP2C9 | |
| SCHEMBL4972816 | 0.83 | ELANE (0.32) | ELANE | |
| SCHEMBL4972810 | 0.83 | ELANE (0.32) | ELANE | |
| SCHEMBL5745520 | 0.83 | ELANE (0.36) | ELANEHCRTR1TP53MAPTALOX15 | |
| SCHEMBL5041462 | 0.83 | ELANE (0.38) | ELANEATP4AATP4BKIF11CYP3A4 | |
| SCHEMBL5044812 | 0.80 | KIF11 (0.38) | ATP4AATP4BKIF11CYP3A4CYP2C9 | |
| SCHEMBL6672735 | 0.77 | ELANE (0.37) | ELANEATP4AATP4BCYP3A4CYP2C9 | |
| SCHEMBL5744048 | 0.77 | ELANE (0.37) | ELANEATP4AATP4BCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476445-A1 | TRICYCLIC N-ACYL COMPOUNDS | ALTANA Pharma AG (DE) | 2004-11-17 | — | — | EP | disclosed |
| WO-2003068774-A1 | TRICYCLIC N-ACYL COMPOUNDS | ALTANA PHARMA AG (DE) | 2003-08-21 | — | — | WO | disclosed |