Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.67 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.67 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.67 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.67 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.67 |
| ▸ | CLK2 | P49760 | 2/20 | 0.67 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.67 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.67 |
| ▸ | MELK | Q14680 | 2/20 | 0.67 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.67 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.67 |
| ▸ | GAK | O14976 | 1/20 | 0.67 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.67 |
| ▸ | JAK2 | O60674 | 1/20 | 0.67 |
| ▸ | NQO2 | P16083 | 1/20 | 0.67 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.67 |
| ▸ | FECH | P22830 | 1/20 | 0.67 |
| ▸ | JAK1 | P23458 | 1/20 | 0.67 |
| ▸ | TYK2 | P29597 | 1/20 | 0.67 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7532858 | 0.91 | MAPK8 (0.71) | MAPK8PRKD3MAP4K4MAPK9CSNK1D | |
| SCHEMBL6509980 | 0.88 | MAPK8 (0.53) | MAPK8PRKD3MAP4K4MAPK9CSNK1D | |
| SCHEMBL5380905 | 0.87 | MAPK8 (0.71) | MAPK8PRKD3MAP4K4MAPK9CSNK1D | |
| SCHEMBL5372290 | 0.84 | MAPK8 (0.67) | MAPK8PRKD3MAP4K4MAPK9CSNK1D | |
| SCHEMBL5374929 | 0.83 | MAPK8 (0.66) | MAPK8PRKD3MAP4K4MAPK9CSNK1D | |
| SCHEMBL5373334 | 0.81 | CLK2 (0.98) | MAPK8PRKD3MAP4K4MAPK9CSNK1D | |
| Cc-401 SCHEMBL30290855 | 0.81 | CLK2 (1.00) | MAPK8PRKD3MAP4K4MAPK9CSNK1D | |
| SCHEMBL5380287 | 0.81 | MAPK8 (0.71) | MAPK8PRKD3MAP4K4MAPK9CSNK1D | |
| SCHEMBL8253744 | 0.81 | CLK2 (1.00) | MAPK8PRKD3MAP4K4MAPK9CSNK1D | |
| Cc-401 SCHEMBL4604749 | 0.81 | CLK2 (1.00) | MAPK8PRKD3MAP4K4MAPK9CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313711-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002010137-A9 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARM INC (US) | 2003-02-06 | — | — | WO | disclosed |
| WO-2002010137-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2002-02-07 | — | — | WO | disclosed |