Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.53 |
| ▸ | CLK2 | P49760 | 2/20 | 0.53 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.53 |
| ▸ | MELK | Q14680 | 2/20 | 0.53 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | GAK | O14976 | 1/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.53 |
| ▸ | NQO2 | P16083 | 1/20 | 0.53 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.53 |
| ▸ | FECH | P22830 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | TYK2 | P29597 | 1/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5386179 | 0.85 | GSK3B (0.52) | MAPK8PRKD3MAP4K4MAPK9CSNK1D | |
| SCHEMBL5377799 | 0.82 | CLK2 (0.53) | MAPK8PRKD3MAP4K4MAPK9CSNK1D | |
| SCHEMBL8365703 | 0.81 | MKNK1 (0.60) | MAPK8PRKD3MAP4K4MAPK9CSNK1D | |
| SCHEMBL5372567 | 0.80 | ENPP2 (0.51) | MAPK8PRKD3MAP4K4MAPK9CSNK1D | |
| SCHEMBL5380918 | 0.80 | MAP2K4 (0.58) | MAPK8PRKD3MAP4K4MAPK9CSNK1D | |
| SCHEMBL599945 | 0.80 | MAP3K5 (0.50) | MAPK8PRKD3MAP4K4MAPK9CSNK1D | |
| SCHEMBL14514437 | 0.80 | MAP2K4 (0.55) | MAPK8PRKD3MAP4K4MAPK9CSNK1D | |
| SCHEMBL7532858 | 0.79 | MAPK8 (0.71) | MAPK8PRKD3MAP4K4MAPK9CSNK1D | |
| SCHEMBL5379398 | 0.77 | MAP3K5 (0.66) | MAPK8PRKD3MAP4K4MAPK9CSNK1D | |
| SCHEMBL5386487 | 0.77 | MAP4K4 (0.47) | MAPK8PRKD3MAP4K4MAPK9CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009876-A1 | Indazole compounds, compositions thereof and methods of treatment therewith | SIGNAL PHARMACEUTICALS, LLC | 2005-01-13 | — | — | US | disclosed |
| US-20020103229-A1 | Indazole derivatives as JNK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC | 2002-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020103229-A1 | Indazole derivatives as JNK inhibitors and compositions and methods related thereto | MAP3K7, MAP3K1, MAP3K8 | MAPK8 25/4885PRKD3 70/4885MAP4K4 41/4885 |
| US-20050009876-A1 | Indazole compounds, compositions thereof and methods of treatment therewith | GPR119, JAK3, IGF1R | MAPK8 91/4885PRKD3 152/4885MAP4K4 178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.