Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 12/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | GLP1R | P43220 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CCR3 | P51677 | 2/20 | 0.43 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7108101 | 1.00 | CCR2 (0.53) | CCR2ADRB2HRH1DRD3GLP1R | |
| SCHEMBL3894271 | 0.84 | CCR2 (0.52) | CCR2ADRB2HRH1DRD3GLP1R | |
| SCHEMBL3885460 | 0.79 | CCR2 (0.53) | CCR2ADRB2HRH1DRD3GLP1R | |
| SCHEMBL3885463 | 0.79 | CCR2 (0.53) | CCR2ADRB2HRH1DRD3GLP1R | |
| SCHEMBL3894274 | 0.76 | CCR2 (0.69) | CCR2ADRB2HRH1DRD3GLP1R | |
| SCHEMBL3428340 | 0.75 | CCR2 (0.58) | CCR2ADRB2HRH1DRD3GLP1R | |
| SCHEMBL3892836 | 0.70 | CCR2 (1.00) | CCR2ADRB2HRH1DRD3GLP1R | |
| SCHEMBL3892832 | 0.70 | CCR2 (1.00) | CCR2ADRB2HRH1DRD3GLP1R | |
| SCHEMBL23570947 | 0.69 | PLK1 (0.59) | RAB9AMEN1KMT2A | |
| SCHEMBL5554295 | 0.69 | CCR2 (0.71) | CCR2ADRB2HRH1DRD3GLP1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343751-A2 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002060859-A2 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-08-08 | — | — | WO | disclosed |