Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.55 |
| ▸ | RHOA | P61586 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6578900 | 0.87 | MAPK1 (0.51) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL7110570 | 0.85 | POLB (0.55) | TOP2ACSNK2A2CSNK2A1NPC1EGFR | |
| SCHEMBL4898607 | 0.84 | BRAF (0.61) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL2995190 | 0.83 | BRAF (0.52) | CSNK2A1EGFR | |
| SCHEMBL3001568 | 0.82 | BRAF (0.53) | MEN1KMT2AEGFR | |
| SCHEMBL3001378 | 0.82 | NFKB1 (0.46) | MEN1KMT2AEGFR | |
| SCHEMBL26434474 | 0.81 | TOP2A (0.68) | TOP2ARHOACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL21473892 | 0.81 | BRAF (0.46) | MEN1KMT2AKDM4EGAA | |
| SCHEMBL2995233 | 0.80 | BRAF (0.51) | CSNK2A1EGFR | |
| SCHEMBL4899889 | 0.79 | EGFR (0.52) | NPC1RAB9AMEN1KMT2AEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347975-A1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | Aventis Pharma S.A. (FR) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002051843-A1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | AVENTIS PHARMA S.A. (FR) | 2002-07-04 | — | — | WO | disclosed |