Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7107692 | 1.00 | PIM1 (0.34) | PIM1PIM3PIM2SCN9A | |
| SCHEMBL7111623 | 1.00 | PIM1 (0.34) | PIM1PIM3PIM2SCN9A | |
| SCHEMBL30755634 | 0.85 | PIM1 (0.31) | PIM1PIM3PIM2 | |
| SCHEMBL8341969 | 0.82 | PIM1 (0.30) | PIM1PIM3PIM2 | |
| SCHEMBL7107697 | 0.82 | PIM1 (0.30) | PIM1PIM3PIM2 | |
| SCHEMBL7107004 | 0.76 | L3MBTL1 (0.32) | — | |
| SCHEMBL7108458 | 0.76 | L3MBTL1 (0.32) | — | |
| SCHEMBL7107007 | 0.76 | L3MBTL1 (0.32) | — | |
| SCHEMBL7108446 | 0.76 | L3MBTL1 (0.32) | — | |
| SCHEMBL10714528 | 0.75 | KDM4E (0.39) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998464-B1 | POLYHYDROXYALKYLPYRAZINE DERIVATIVES, THEIR PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-15 | — | — | EP | claimed |
| US-6362185-B1 | Polyhydroxyalkylpyrazine derivatives, their preparation and the medicaments comprising them | AVENTIS PHARMA S.A. (FR) | 2002-03-26 | — | — | US | claimed |
| EP-0998464-B1 | POLYHYDROXYALKYLPYRAZINE DERIVATIVES, THEIR PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-15 | — | — | EP | disclosed |
| US-6362185-B1 | Polyhydroxyalkylpyrazine derivatives, their preparation and the medicaments comprising them | AVENTIS PHARMA S.A. (FR) | 2002-03-26 | — | — | US | disclosed |