Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 12/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5035472 | 0.88 | LSS (0.45) | LSSMAOAMAOBRAB9ADRD2 | |
| SCHEMBL5140624 | 0.83 | LSS (0.48) | LSSMAOAMAOBKDM4E | |
| SCHEMBL5140921 | 0.81 | LSS (0.47) | LSS | |
| SCHEMBL5140147 | 0.81 | ATM (0.51) | LSSMAOBRAB9AHRH2HRH1 | |
| SCHEMBL5140748 | 0.81 | LSS (0.53) | LSS | |
| SCHEMBL5140171 | 0.81 | LSS (0.70) | LSS | |
| SCHEMBL5139757 | 0.79 | LSS (0.54) | LSSMAOB | |
| SCHEMBL5140211 | 0.79 | LSS (0.44) | LSSMAOAMAOB | |
| SCHEMBL5040015 | 0.75 | PPARD (0.36) | LSSMAOAMAOB | |
| SCHEMBL5140389 | 0.70 | AGER (0.40) | MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334094-B1 | CHOLESTEROL LOWERING BENZO[B]THIOPHENES AND BENZO[D]ISOTHIAZOLES | HOFFMANN LA ROCHE (CH) | 2004-12-29 | — | — | EP | claimed |