Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.44 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.44 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | HTT | P42858 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | RAD52 | P43351 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | RGS12 | O14924 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9149699 | 1.00 | KCNH2 (0.53) | KCNH2SMN1; SMN2NPC1RAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL28520493 | 1.00 | KCNH2 (0.53) | KCNH2SMN1; SMN2NPC1RAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL9119728 | 1.00 | KCNH2 (0.53) | KCNH2SMN1; SMN2NPC1RAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL10450713 | 1.00 | KCNH2 (0.53) | KCNH2SMN1; SMN2NPC1RAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL16556169 | 1.00 | KCNH2 (0.53) | KCNH2SMN1; SMN2NPC1RAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL28496507 | 1.00 | KCNH2 (0.53) | KCNH2SMN1; SMN2NPC1RAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL9149706 | 1.00 | KCNH2 (0.53) | KCNH2SMN1; SMN2NPC1RAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL9489538 | 1.00 | KCNH2 (0.53) | KCNH2SMN1; SMN2NPC1RAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL16556082 | 1.00 | KCNH2 (0.53) | KCNH2SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL5283398 | 0.98 | KCNH2 (0.55) | KCNH2SMN1; SMN2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9968537-B2 | Anti-dandruff compositions and hair care formulations containing zinc pyrithione and quaternary ammonium salt | JUBILANT INGREVIA LIMITED (IN) | 2018-05-15 | — | — | US | claimed |
| US-20160374914-A2 | ANTI-DANDRUFF COMPOSITIONS AND HAIR CARE FORMULATIONS CONTAINING ZINC PYRITHIONE AND QUATERNARY AMMONIUM SALT | JUBILANT LIFE SCIENCES LTD (IN) | 2016-12-29 | — | — | US | claimed |
| US-20160220468-A1 | ANTI-DANDRUFF COMPOSITIONS AND HAIR CARE FORMULATIONS CONTAINING ZINC PYRITHIONE AND QUATERNARY AMMONIUM SALT | JUBILANT INGREVIA LIMITED (IN) | 2016-08-04 | — | — | US | claimed |
| EP-3041356-A1 | ANTI-DANDRUFF COMPOSITIONS AND HAIR CARE FORMULATIONS CONTAINING ZINC PYRITHIONE AND QUATERNARY AMMONIUM SALT | Jubilant Life Sciences Limited (IN) | 2016-07-13 | — | — | EP | claimed |
| WO-2015033351-A1 | ANTI-DANDRUFF COMPOSITIONS AND HAIR CARE FORMULATIONS CONTAINING ZINC PYRITHIONE AND QUATERNARY AMMONIUM SALT | JUBILANT LIFE SCIENCES LIMITED (IN) | 2015-03-12 | — | — | WO | claimed |
| US-5741823-A | Polymerized latex emulsion suitable for producing coating on reconstituted wood substrate | ROHM AND HAAS COMPANY (US) | 1998-04-21 | — | — | US | claimed |
| US-5635248-A | FORMING POLYMERIZED LATEX EMULSION COMPRISING ETHYLENICALLY UNSATURATED MONOMER, FOAMING AGENT, APPLYING TO SURFACE, DRYING, CRUSHING, CURING | ROHM AND HAAS COMPANY (US) | 1997-06-03 | — | — | US | claimed |
| US-5616419-A | COATING WITH POLYMER FROM UNSATURATED MONOMER, APPLYING FOAMED, POLYMERIZED LATEX TO SURFACE OF WOOD, DRYING TO HARDEN, CRUSHING, CURING | ROHM AND HAAS COMPANY (US) | 1997-04-01 | — | — | US | claimed |
| EP-0747134-A2 | Coating on reconstituted wood substrate and foamable latex binder therefor | ROHM AND HAAS COMPANY (US) | 1996-12-11 | — | — | EP | claimed |
| EP-3041356-B1 | ANTI-DANDRUFF COMPOSITIONS AND HAIR CARE FORMULATIONS CONTAINING ZINC PYRITHIONE AND QUATERNARY AMMONIUM SALT | JUBILANT LIFE SCIENCES LTD (IN) | 2020-12-16 | — | — | EP | disclosed |
| US-9968537-B2 | Anti-dandruff compositions and hair care formulations containing zinc pyrithione and quaternary ammonium salt | JUBILANT INGREVIA LIMITED (IN) | 2018-05-15 | — | — | US | disclosed |
| US-20160374914-A2 | ANTI-DANDRUFF COMPOSITIONS AND HAIR CARE FORMULATIONS CONTAINING ZINC PYRITHIONE AND QUATERNARY AMMONIUM SALT | JUBILANT LIFE SCIENCES LTD (IN) | 2016-12-29 | — | — | US | disclosed |
| US-20160220468-A1 | ANTI-DANDRUFF COMPOSITIONS AND HAIR CARE FORMULATIONS CONTAINING ZINC PYRITHIONE AND QUATERNARY AMMONIUM SALT | JUBILANT INGREVIA LIMITED (IN) | 2016-08-04 | — | — | US | disclosed |
| EP-3041356-A1 | ANTI-DANDRUFF COMPOSITIONS AND HAIR CARE FORMULATIONS CONTAINING ZINC PYRITHIONE AND QUATERNARY AMMONIUM SALT | Jubilant Life Sciences Limited (IN) | 2016-07-13 | — | — | EP | disclosed |
| EP-0196029-A2 | Vacuum guide used in flexible sheet material treatment | UNION CARBIDE CORPORATION (US) | 1986-10-01 | — | — | EP | disclosed |
| EP-0195458-A1 | Process for treating wet paper with foam | UNION CARBIDE CORPORATION (US) | 1986-09-24 | — | — | EP | disclosed |
| US-4581254-A | Foam applicator used in paper treatment | UNION CARBIDE CORPORATION (US) | 1986-04-08 | — | — | US | disclosed |
| US-4562097-A | WASH AND WEAR, DYEING | UNION CARBIDE CORPORATION (US) | 1985-12-31 | — | — | US | disclosed |
| US-4099913-A | FROTHS | UNION CARBIDE CORPORATION (US) | 1978-07-11 | — | — | US | disclosed |
| US-4023526-A | Apparatus for application of foam to a substrate | UNION CARBIDE CORPORATION (US) | 1977-05-17 | — | — | US | disclosed |