Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 2/20 | 0.51 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.44 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16758710 | 0.81 | MAP3K5 (0.69) | MAP3K5POLBPIN1HSD17B10CYP1A2 | |
| SCHEMBL25402245 | 0.78 | POLB (0.71) | POLBPIN1TMIGD3HTR2CHTR2B | |
| SCHEMBL31439407 | 0.75 | PAK1 (0.71) | PAK1HSD17B10CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2115555 | 0.75 | PAK1 (0.71) | PAK1HSD17B10CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16146535 | 0.75 | XDH (0.56) | XDHMAP3K5TMIGD3HTR2CHTR2B | |
| Alcohol SCHEMBL27897029 | 0.73 | DPP4 (0.54) | XDHTMIGD3HTR2CHTR2BCDK1 | |
| SCHEMBL4451634 | 0.72 | XDH (0.61) | XDHTMIGD3HTR2CHTR2BDPP4 | |
| SCHEMBL24500763 | 0.72 | XDH (0.56) | XDHTMIGD3HTR2CHTR2BCDK2 | |
| SCHEMBL1443987 | 0.71 | PDPK1 (0.56) | XDHPIN1TMIGD3HTR2CHTR2B | |
| SCHEMBL5839305 | 0.71 | XDH (0.51) | XDHTMIGD3HTR2CHTR2BDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200435-B1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | NOVARTIS AG (CH) | 2003-10-01 | — | — | EP | disclosed |
| US-6589950-B1 | Treatment of inflammatory or obstructive airways disease for respiratory system disorders | NOVARTIS AG (CH) | 2003-07-08 | — | — | US | disclosed |
| EP-1200435-A1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | Novartis AG (CH) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001009134-A1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | NOVARTIS AG (CH) | 2001-02-08 | — | — | WO | disclosed |