Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | CTSB | P07858 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.41 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.41 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7112387 | 0.77 | KCNJ11 (0.66) | MAPTALDH1A1HPGDKCNJ11ABCC9 | |
| SCHEMBL7113364 | 0.75 | KDM4E (0.75) | MAPTKDM4EMEN1KMT2AHTT | |
| SCHEMBL8687725 | 0.74 | CTSB (0.77) | MAPTKDM4EMEN1KMT2AHTT | |
| SCHEMBL7117432 | 0.74 | KDM4E (0.73) | MAPTKDM4EMEN1KMT2AHTT | |
| SCHEMBL15346485 | 0.73 | CTSB (0.65) | MAPTKDM4EMEN1KMT2AHTT | |
| SCHEMBL9386016 | 0.73 | CTSB (0.69) | MAPTKDM4EMEN1KMT2AHTT | |
| SCHEMBL7115687 | 0.72 | MEN1 (0.65) | MAPTKDM4EMEN1KMT2AHTT | |
| SCHEMBL7115829 | 0.71 | KDM4E (0.67) | MAPTKDM4EMEN1KMT2AHTT | |
| SCHEMBL22234054 | 0.70 | CTSB (0.65) | MAPTKDM4EMEN1KMT2AHTT | |
| SCHEMBL3609722 | 0.70 | CTSB (1.00) | MAPTKDM4EMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030199578-A1 | Naphthalene amides as potassium channel openers | ABBOTT LABORATORIES | 2003-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199578-A1 | Naphthalene amides as potassium channel openers | KCNJ2, KCNN2, KCNJ1 | MAPT 1450/4885KDM4E 1005/4885MEN1 982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.