Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 1/20 | 0.60 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.60 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7111815 | 0.92 | ABCC9 (0.61) | ABCC9ABCC8KCNJ11ALDH1A1SMN1; SMN2 | |
| SCHEMBL6191744 | 0.89 | ABCC9 (0.66) | ABCC9ABCC8KCNJ11ALDH1A1SMN1; SMN2 | |
| SCHEMBL4264927 | 0.85 | MAPT (0.66) | ABCC9ABCC8KCNJ11ALDH1A1SMN1; SMN2 | |
| SCHEMBL7111310 | 0.85 | MAPT (0.66) | ABCC9ABCC8KCNJ11ALDH1A1SMN1; SMN2 | |
| SCHEMBL7110369 | 0.84 | MAPT (0.50) | ALDH1A1SMN1; SMN2HPGDALOX12KMT2A | |
| SCHEMBL7111813 | 0.83 | ABCC9 (0.59) | ABCC9ABCC8KCNJ11ALDH1A1SMN1; SMN2 | |
| SCHEMBL7111814 | 0.83 | ABCC9 (0.59) | ABCC9ABCC8KCNJ11ALDH1A1SMN1; SMN2 | |
| SCHEMBL7112525 | 0.82 | ABCC9 (0.60) | ABCC9ABCC8KCNJ11ALDH1A1SMN1; SMN2 | |
| SCHEMBL7112530 | 0.82 | ABCC9 (0.60) | ABCC9ABCC8KCNJ11ALDH1A1SMN1; SMN2 | |
| SCHEMBL4702222 | 0.80 | ABCC9 (0.58) | ABCC9ABCC8KCNJ11ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183236-B1 | CINNAMOYLAMINOALKYL-SUBSTITUTED BENZENESULFONAMIDE DERIVATIVES | AVENTIS PHARMA GMBH (DE) | 2003-10-22 | — | — | EP | disclosed |
| EP-1183236-A1 | CINNAMOYLAMINOALKYL-SUBSTITUTED BENZENESULFONAMIDE DERIVATIVES | Aventis Pharma Deutschland GmbH (DE) | 2002-03-06 | — | — | EP | disclosed |
| US-6350778-B1 | CARDIOVASCULAR DISORDERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-02-26 | — | — | US | disclosed |
| WO-2000071513-A1 | CINNAMOYLAMINOALKYL-SUBSTITUTED BENZENESULFONAMIDE DERIVATIVES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-30 | — | — | WO | disclosed |