Propiolactone

Propiolactone

SCHEMBL711357

C=CCNc1cccc2c1C(=O)c1ccccc1C2=O.O=C1CCO1

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 7/20 0.46
MEN1 O00255 6/20 0.46
MAPT P10636 5/20 0.46
L3MBTL1 Q9Y468 4/20 0.46
ALDH1A1 P00352 3/20 0.46
MAPK1 P28482 3/20 0.46
POLB P06746 3/20 0.46
EGFR P00533 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
LMNA P02545 2/20 0.46
HTT P42858 2/20 0.46
RAD52 P43351 2/20 0.46
BLM P54132 2/20 0.46
RECQL P46063 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
RAB9A P51151 2/20 0.46
TDP1 Q9NUW8 2/20 0.46
PABPC1 P11940 2/20 0.46
NSD2 O96028 3/20 0.44
MITF O75030 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1906212 0.89 MAPT (0.56) KMT2AMEN1MAPTL3MBTL1ALDH1A1
SCHEMBL6063381 0.85 NSD2 (0.49) KMT2AMEN1MAPTL3MBTL1ALDH1A1
SCHEMBL728509 0.83 KMT2A (0.47) KMT2AMEN1MAPTL3MBTL1ALDH1A1
SCHEMBL5420918 0.79 KMT2A (0.57) KMT2AMEN1MAPTL3MBTL1ALDH1A1
SCHEMBL11408020 0.75 ALDH1A1 (0.42) KMT2AMEN1MAPTL3MBTL1ALDH1A1
SCHEMBL9027405 0.74 KMT2A (0.49) KMT2AMEN1MAPTL3MBTL1ALDH1A1
SCHEMBL11848356 0.74 NSD2 (0.43) KMT2AMEN1MAPTL3MBTL1ALDH1A1
SCHEMBL7122672 0.72 MAPT (0.53) KMT2AMEN1MAPTL3MBTL1ALDH1A1
SCHEMBL12658834 0.72 MAPT (0.53) KMT2AMEN1MAPTL3MBTL1ALDH1A1
SCHEMBL7129853 0.72 MAPT (0.53) KMT2AMEN1MAPTL3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023068316-A1 MATERIAL FOR SOFT CONTACT LENS HAVING CONTRAST IMPROVEMENT FUNCTION 興和株式会社 2023-04-27 WO disclosed
US-20210163650-A1 POLYMER MATERIAL MENICON CO., LTD. (JP) 2021-06-03 US disclosed
EP-3822296-A1 POLYMER MATERIAL Menicon Co., Ltd. (JP) 2021-05-19 EP disclosed
WO-2021020512-A1 DRUG-CONTAINING OPHTHALMIC LENS 興和株式会社 2021-02-04 WO disclosed
EP-3086162-B1 OCULAR LENS MENICON CO LTD (JP) 2019-04-17 EP disclosed
US-20180356561-A1 GEL, GEL MANUFACTURING METHOD, LENS, CONTACT LENS SURFACE MODIFIER, POLYMERIZABLE COMPOSITION, AND POLYMER JSR CORPORATION (JP) 2018-12-13 US disclosed
EP-3086163-B1 POLYSILOXANE-BASED MACROMONOMER FOR USE IN OCULAR LENS AND OCULAR LENS USING SAME MENICON CO LTD (JP) 2018-11-14 EP disclosed
EP-2857459-B1 STABLE POLYMERIZABLE UV-ABSORBING COLORANT FOR INTRAOCULAR LENS KOWA CO (JP) 2017-12-27 EP disclosed
US-9657131-B2 Ophthalmic lens MENICON CO., LTD. (JP) 2017-05-23 US disclosed
US-9650473-B2 Polysiloxane-based macromonomer for ophthalmic lens and ophthalmic lens using the same MENICON CO., LTD. (JP) 2017-05-16 US disclosed
US-5416132-A Acrylamide modified acrylate modified polysiloxanes MENICON CO., LTD. (JP) 1995-05-16 US disclosed
US-5416180-A Fluorine containing (meth)acrylate polymers MENICON CO., LTD. (JP) 1995-05-16 US disclosed
EP-0381005-B1 Ocular lens material MENICON CO LTD (JP) 1995-01-11 EP disclosed
US-5346946-A Polysiloxane macromonomer MENICON CO., LTD (JP) 1994-09-13 US disclosed
EP-0600269-A2 Soft ocular lens material Menicon Co., Ltd. (JP) 1994-06-08 EP disclosed
EP-0584826-A2 Ocular lens material Menicon Co., Ltd. (JP) 1994-03-02 EP disclosed
EP-0584764-A1 Ocular lens material Menicon Co., Ltd. (JP) 1994-03-02 EP disclosed
EP-0578087-A2 Ocular lens material Menicon Co., Ltd. (JP) 1994-01-12 EP disclosed
US-4954586-A COPOLYMER OF A FLUORINE CONTAINING (METH)ACRYLATE, AN ALKYL (METH)ACRYLATE, A POLYSILOXANE AND A URETHANE CONTAINING POLYSILOXANE MENICON CO., LTD (JP) 1990-09-04 US disclosed
EP-0379146-A2 Soft ocular lens material Menicon Co., Ltd. (JP) 1990-07-25 EP disclosed