Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 3/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.47 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.47 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.47 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 2/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3636122 | 0.81 | NR1H4 (0.56) | LRRK2PARP1BAZ2BBAZ2APRKCI | |
| SCHEMBL1347851 | 0.79 | ERN1 (0.49) | LRRK2PARP1AKR1C3AKR1C2BAZ2B | |
| SCHEMBL28784391 | 0.78 | PARP1 (0.51) | LRRK2PARP1AKR1C3AKR1C2BAZ2B | |
| SCHEMBL1787533 | 0.77 | PARP1 (0.56) | LRRK2PARP1AKR1C3AKR1C2BAZ2B | |
| Hydrochloric Acid SCHEMBL18138750 | 0.77 | PARP1 (0.50) | LRRK2PARP1AKR1C3AKR1C2BAZ2B | |
| SCHEMBL3135455 | 0.76 | PARP1 (0.53) | LRRK2PARP1BAZ2BBAZ2APRKCI | |
| SCHEMBL2026285 | 0.76 | ESR2 (0.55) | LRRK2PARP1DHODH | |
| SCHEMBL4262253 | 0.75 | PARP1 (0.60) | LRRK2PARP1BAZ2BBAZ2AMAP2K4 | |
| Hydrochloric Acid SCHEMBL29287792 | 0.75 | PARP1 (0.51) | LRRK2PARP1BAZ2BBAZ2APRKCI | |
| Hydrochloric Acid SCHEMBL29287827 | 0.75 | PARP1 (0.51) | LRRK2PARP1BAZ2BBAZ2APRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047665-B1 | MATRIX METALLOPROTEASE INHIBITORS | PFIZER LTD (GB) | 2003-10-22 | — | — | EP | disclosed |
| US-6350907-B1 | PEPTIDE ENZYME INHIBITORS | PFIZER INC | 2002-02-26 | — | — | US | disclosed |
| EP-1047665-A1 | MATRIX METALLOPROTEASE INHIBITORS | Pfizer Limited (GB) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999035124-A1 | MATRIX METALLOPROTEASE INHIBITORS | PFIZER LIMITED (GB) | 1999-07-15 | — | — | WO | disclosed |