Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.36 |
| ▸ | ITGAM | P11215 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4830357 | 0.81 | KDM4E (0.55) | KDM4ERAB9AMEN1PKMMAPK1 | |
| Perchlorate SCHEMBL7256390 | 0.76 | KDM4E (0.50) | KDM4ERAB9AMEN1PKMMAPK1 | |
| SCHEMBL16791363 | 0.73 | ITGB2 (0.51) | KDM4ERAB9AMEN1PKMMAPK1 | |
| Iodide SCHEMBL1326180 | 0.73 | MAPT (0.53) | KDM4ERAB9AMEN1PKMMAPK1 | |
| Iodide SCHEMBL5892553 | 0.73 | MAPT (0.53) | KDM4ERAB9AMEN1PKMMAPK1 | |
| SCHEMBL7252269 | 0.72 | KDM4E (0.56) | KDM4ERAB9AMEN1PKMMAPK1 | |
| SCHEMBL31623888 | 0.72 | KDM4E (0.56) | KDM4ERAB9AMEN1PKMMAPK1 | |
| Iodide SCHEMBL5892501 | 0.72 | KDM4E (0.43) | KDM4ERAB9AMEN1KMT2ATDP1 | |
| SCHEMBL9433682 | 0.71 | MAPT (0.54) | KDM4ERAB9AMEN1PKMMAPK1 | |
| Water SCHEMBL10949547 | 0.70 | MAPT (0.33) | KDM4ERAB9AMEN1PKMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030145394-A1 | Helium-neon excitable reticulocyte dyes derivable from halolepidines | WANG NAI-YI (US) | 2003-08-07 | — | — | US | claimed |
| EP-0944672-B1 | HELIUM-NEON EXCITABLE RETICULOCYTE DYES DERIVABLE FROM HALOLEPIDINES | ABBOTT LAB (US) | 2002-09-04 | — | — | EP | claimed |
| EP-0944672-A1 | HELIUM-NEON EXCITABLE RETICULOCYTE DYES DERIVABLE FROM HALOLEPIDINES | Abbott Laboratories (US) | 1999-09-29 | — | — | EP | claimed |
| WO-1998026007-A1 | HELIUM-NEON EXCITABLE RETICULOCYTE DYES DERIVABLE FROM HALOLEPIDINES | ABBOTT LABORATORIES (US) | 1998-06-18 | — | — | WO | claimed |
| US-6495692-B1 | A METHOD FOR SYNTHESIZING DYES EXCITABLE BY A HELIUM-NEON LASER (EXCITABLE AT 633 NM) FROM HOLOLEPIDINES, E. G., 7-HALOLEPIDINE, WHICH DYES ARE SUITABLE FOR THE DETECTION AND ENUMERATION OF RETICULOCYTES IN HUMAN BLOOD SAMPLES. | ABBOTT LABORATORIES | 2002-12-17 | — | — | US | disclosed |
| EP-0944672-B1 | HELIUM-NEON EXCITABLE RETICULOCYTE DYES DERIVABLE FROM HALOLEPIDINES | ABBOTT LAB (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-0944672-A1 | HELIUM-NEON EXCITABLE RETICULOCYTE DYES DERIVABLE FROM HALOLEPIDINES | Abbott Laboratories (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998026007-A1 | HELIUM-NEON EXCITABLE RETICULOCYTE DYES DERIVABLE FROM HALOLEPIDINES | ABBOTT LABORATORIES (US) | 1998-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030145394-A1 | Helium-neon excitable reticulocyte dyes derivable from halolepidines | HCLS1, HNRNPH3, HBG2 | KDM4E 2799/4885RAB9A 381/4885MEN1 4757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.