Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | HNF4A | P41235 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8021802 | 0.81 | KDM4E (0.41) | KDM4EMAPTNPC1RAB9ATDP1 | |
| Perchlorate SCHEMBL7250930 | 0.76 | KDM4E (0.41) | KDM4EMAPTNPC1RAB9ATDP1 | |
| Iodide SCHEMBL5892415 | 0.73 | KDM4E (0.40) | KDM4EMEN1KMT2AL3MBTL1ALDH1A1 | |
| Iodide SCHEMBL7114184 | 0.72 | KDM4E (0.43) | KDM4EMAPTRAB9ATDP1MEN1 | |
| SCHEMBL7254059 | 0.70 | KDM4E (0.53) | KDM4EMAPTNPC1RAB9ATDP1 | |
| Hydrochloric Acid SCHEMBL460640 | 0.66 | KDM4E (0.42) | KDM4EMAPTTDP1APEX1ALDH1A1 | |
| SCHEMBL8385263 | 0.65 | KDM4E (0.50) | KDM4EMAPTNPC1RAB9ATDP1 | |
| SCHEMBL6403566 | 0.63 | GAA (0.48) | KDM4EMAPTNPC1RAB9AMEN1 | |
| SCHEMBL460353 | 0.63 | KDM4E (0.49) | KDM4ETDP1HTTSMN1; SMN2ALDH1A1 | |
| Bromide SCHEMBL4272661 | 0.62 | GAA (0.47) | KDM4EMAPTNPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030145394-A1 | Helium-neon excitable reticulocyte dyes derivable from halolepidines | WANG NAI-YI (US) | 2003-08-07 | — | — | US | claimed |
| EP-0944672-B1 | HELIUM-NEON EXCITABLE RETICULOCYTE DYES DERIVABLE FROM HALOLEPIDINES | ABBOTT LAB (US) | 2002-09-04 | — | — | EP | claimed |
| EP-0944672-A1 | HELIUM-NEON EXCITABLE RETICULOCYTE DYES DERIVABLE FROM HALOLEPIDINES | Abbott Laboratories (US) | 1999-09-29 | — | — | EP | claimed |
| WO-1998026007-A1 | HELIUM-NEON EXCITABLE RETICULOCYTE DYES DERIVABLE FROM HALOLEPIDINES | ABBOTT LABORATORIES (US) | 1998-06-18 | — | — | WO | claimed |
| US-7083982-B2 | Helium-neon excitable reticulocyte dyes derivable from halolepidines | ABBOTT LABORATORIES (US) | 2006-08-01 | — | — | US | disclosed |
| US-20030145394-A1 | Helium-neon excitable reticulocyte dyes derivable from halolepidines | WANG NAI-YI (US) | 2003-08-07 | — | — | US | disclosed |
| US-6495692-B1 | A METHOD FOR SYNTHESIZING DYES EXCITABLE BY A HELIUM-NEON LASER (EXCITABLE AT 633 NM) FROM HOLOLEPIDINES, E. G., 7-HALOLEPIDINE, WHICH DYES ARE SUITABLE FOR THE DETECTION AND ENUMERATION OF RETICULOCYTES IN HUMAN BLOOD SAMPLES. | ABBOTT LABORATORIES | 2002-12-17 | — | — | US | disclosed |
| EP-0944672-B1 | HELIUM-NEON EXCITABLE RETICULOCYTE DYES DERIVABLE FROM HALOLEPIDINES | ABBOTT LAB (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-0944672-A1 | HELIUM-NEON EXCITABLE RETICULOCYTE DYES DERIVABLE FROM HALOLEPIDINES | Abbott Laboratories (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998026007-A1 | HELIUM-NEON EXCITABLE RETICULOCYTE DYES DERIVABLE FROM HALOLEPIDINES | ABBOTT LABORATORIES (US) | 1998-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030145394-A1 | Helium-neon excitable reticulocyte dyes derivable from halolepidines | HCLS1, HNRNPH3, HBG2 | KDM4E 2799/4885MAPT 3052/4885NPC1 2102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.