Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.48 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.44 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.44 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7114274 | 1.00 | HDAC8 (0.49) | HDAC8PTGER4PTGER3ACHEMAPT | |
| SCHEMBL7112814 | 0.89 | PTGER4 (0.51) | HDAC8PTGER4PTGER3ACHEMAPT | |
| SCHEMBL7112818 | 0.89 | PTGER4 (0.51) | HDAC8PTGER4PTGER3ACHEMAPT | |
| SCHEMBL7107471 | 0.80 | LY96 (0.52) | PTGER4PTGER3ACHEMAPTABCC9 | |
| SCHEMBL7107467 | 0.80 | LY96 (0.52) | PTGER4PTGER3ACHEMAPTABCC9 | |
| SCHEMBL4256436 | 0.80 | ABCC9 (0.59) | PTGER4PTGER3ACHEMAPTABCC9 | |
| SCHEMBL7113055 | 0.80 | ABCC9 (0.59) | PTGER4PTGER3ACHEMAPTABCC9 | |
| SCHEMBL7108290 | 0.79 | LY96 (0.52) | HDAC8ACHEMAPTABCC9ABCC8 | |
| SCHEMBL7108288 | 0.79 | LY96 (0.52) | HDAC8ACHEMAPTABCC9ABCC8 | |
| SCHEMBL5578528 | 0.79 | ABCC9 (0.53) | HDAC8ACHEMAPTABCC9ABCC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1243730-C | Cinnamoylaminoalkyl-substd. benzenesulfonamide derivs. | AVENTIS PHARMA GMBH (DE) | 2006-03-01 | — | — | CN | disclosed |
| EP-1183236-B1 | CINNAMOYLAMINOALKYL-SUBSTITUTED BENZENESULFONAMIDE DERIVATIVES | AVENTIS PHARMA GMBH (DE) | 2003-10-22 | — | — | EP | disclosed |
| CN-1360571-A | Cinnamoylaminoalkyl-substd. benzenesulfonamide derivs. | AVENTIS PHARMA GMBH (DE) | 2002-07-24 | — | — | CN | disclosed |
| EP-1183236-A1 | CINNAMOYLAMINOALKYL-SUBSTITUTED BENZENESULFONAMIDE DERIVATIVES | Aventis Pharma Deutschland GmbH (DE) | 2002-03-06 | — | — | EP | disclosed |
| US-6350778-B1 | CARDIOVASCULAR DISORDERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-02-26 | — | — | US | disclosed |
| WO-2000071513-A1 | CINNAMOYLAMINOALKYL-SUBSTITUTED BENZENESULFONAMIDE DERIVATIVES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-30 | — | — | WO | disclosed |