Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 6/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.52 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 7/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7111627 | 0.88 | KIT (0.61) | AAK1GSK3BMAP3K11KITNTRK1 | |
| SCHEMBL7115613 | 0.86 | AAK1 (0.57) | AAK1GSK3BMAP3K11MAP4K1KIT | |
| SCHEMBL7119150 | 0.85 | MAP3K11 (0.54) | AAK1GSK3BMAP3K11KITNTRK1 | |
| SCHEMBL7113034 | 0.82 | MAP3K11 (0.52) | AAK1GSK3BMAP3K11KITNTRK1 | |
| SCHEMBL7118425 | 0.81 | MAP3K11 (0.51) | AAK1GSK3BMAP3K11MAP4K1KIT | |
| SCHEMBL1516586 | 0.75 | AAK1 (0.65) | AAK1MAP3K11MAP4K1KITDYRK1A | |
| SCHEMBL12762883 | 0.74 | MAP4K1 (0.69) | AAK1GSK3BMAP3K11MAP4K1KIT | |
| SCHEMBL12763532 | 0.73 | DYRK1A (0.73) | AAK1MAP3K11KITDYRK1A | |
| SCHEMBL1516821 | 0.73 | KIT (0.70) | AAK1MAP3K11KITDYRK1ALRRK2 | |
| SCHEMBL7112799 | 0.72 | KIT (0.53) | AAK1MAP3K11KITDYRK1ALRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028724-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |