Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.54 |
| ▸ | AAK1 | Q2M2I8 | 7/20 | 0.51 |
| ▸ | KIT | P10721 | 6/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.48 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7113034 | 0.90 | MAP3K11 (0.52) | MAP3K11AAK1KITNTRK1CHEK1 | |
| SCHEMBL7118425 | 0.89 | MAP3K11 (0.51) | MAP3K11AAK1KITNTRK1CHEK1 | |
| SCHEMBL7111627 | 0.88 | KIT (0.61) | MAP3K11AAK1KITNTRK1DYRK1A | |
| Salicylic Acid SCHEMBL7115608 | 0.85 | AAK1 (0.56) | MAP3K11AAK1KITNTRK1DYRK1A | |
| SCHEMBL7119154 | 0.83 | KIT (0.55) | MAP3K11AAK1KITNTRK1NEK1 | |
| SCHEMBL7113040 | 0.76 | KIT (0.52) | MAP3K11AAK1KITNTRK1DYRK1A | |
| SCHEMBL7118428 | 0.75 | KIT (0.52) | MAP3K11AAK1KITNTRK1DYRK1A | |
| SCHEMBL7115613 | 0.74 | AAK1 (0.57) | MAP3K11AAK1KITNTRK1DYRK1A | |
| SCHEMBL7116259 | 0.74 | AAK1 (0.86) | AAK1KITNEK1 | |
| SCHEMBL12763532 | 0.73 | DYRK1A (0.73) | MAP3K11AAK1KITDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028724-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |