Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 12/20 | 0.82 |
| ▸ | AXL | P30530 | 8/20 | 0.65 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.63 |
| ▸ | PIM1 | P11309 | 2/20 | 0.63 |
| ▸ | NEK2 | P51955 | 2/20 | 0.63 |
| ▸ | STK3 | Q13188 | 2/20 | 0.63 |
| ▸ | GAK | O14976 | 1/20 | 0.63 |
| ▸ | STK16 | O75716 | 1/20 | 0.63 |
| ▸ | STK11 | Q15831 | 1/20 | 0.63 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.63 |
| ▸ | SGK1 | O00141 | 2/20 | 0.62 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.62 |
| ▸ | CDK8 | P49336 | 1/20 | 0.59 |
| ▸ | CDC7 | O00311 | 1/20 | 0.59 |
| ▸ | PLK4 | O00444 | 1/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.59 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7118330 | 0.93 | AAK1 (0.79) | AAK1AXLTNIKPIM1NEK2 | |
| SCHEMBL7112349 | 0.91 | AAK1 (1.00) | AAK1AXLTNIKPIM1NEK2 | |
| SCHEMBL7116989 | 0.91 | AAK1 (0.72) | AAK1AXLTNIKPIM1NEK2 | |
| SCHEMBL7111896 | 0.89 | AAK1 (0.67) | AAK1AXLSGK1CAMKK2NTRK1 | |
| SCHEMBL7117898 | 0.89 | AAK1 (0.76) | AAK1AXLNEK2STK3SGK1 | |
| SCHEMBL7119471 | 0.87 | AAK1 (0.74) | AAK1AXLTNIKPIM1NEK2 | |
| SCHEMBL7118371 | 0.87 | AAK1 (0.67) | AAK1AXLTNIKPIM1NEK2 | |
| SCHEMBL7116265 | 0.86 | AAK1 (0.73) | AAK1AXLTNIKPIM1NEK2 | |
| SCHEMBL7120928 | 0.86 | AAK1 (0.73) | AAK1AXLTNIKPIM1NEK2 | |
| SCHEMBL16945140 | 0.82 | AAK1 (0.61) | AAK1AXLTNIKPIM1NEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028724-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | claimed |
| WO-2003028724-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |