Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 12/20 | 1.00 |
| ▸ | AXL | P30530 | 6/20 | 0.77 |
| ▸ | GAK | O14976 | 1/20 | 0.77 |
| ▸ | STK16 | O75716 | 1/20 | 0.77 |
| ▸ | PIM1 | P11309 | 1/20 | 0.77 |
| ▸ | NEK2 | P51955 | 1/20 | 0.77 |
| ▸ | STK3 | Q13188 | 1/20 | 0.77 |
| ▸ | STK11 | Q15831 | 1/20 | 0.77 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.77 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.77 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.56 |
| ▸ | SGK1 | O00141 | 1/20 | 0.55 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7113082 | 0.91 | AAK1 (0.84) | AAK1AXLGAKSTK16PIM1 | |
| SCHEMBL7118403 | 0.91 | AAK1 (0.82) | AAK1AXLGAKSTK16PIM1 | |
| SCHEMBL7115610 | 0.90 | AAK1 (0.82) | AAK1AXLGAKSTK16PIM1 | |
| SCHEMBL7118330 | 0.88 | AAK1 (0.79) | AAK1AXLGAKSTK16PIM1 | |
| SCHEMBL7114376 | 0.88 | AAK1 (0.79) | AAK1AXLGAKSTK16PIM1 | |
| SCHEMBL7120496 | 0.88 | AAK1 (0.79) | AAK1AXLGAKSTK16PIM1 | |
| SCHEMBL7113762 | 0.87 | AAK1 (0.77) | AAK1AXLGAKSTK16PIM1 | |
| SCHEMBL7121484 | 0.87 | AAK1 (0.80) | AAK1AXLGAKSTK16PIM1 | |
| SCHEMBL7120086 | 0.87 | AAK1 (0.80) | AAK1AXLGAKSTK16PIM1 | |
| SCHEMBL7119909 | 0.87 | AAK1 (1.00) | AAK1AXLGAKSTK16PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028724-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |