Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 15/20 | 0.71 |
| ▸ | KDR | P35968 | 10/20 | 0.68 |
| ▸ | KIF5B | P33176 | 9/20 | 0.68 |
| ▸ | EGFR | P00533 | 5/20 | 0.66 |
| ▸ | JAK3 | P52333 | 2/20 | 0.63 |
| ▸ | GAK | O14976 | 1/20 | 0.63 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.63 |
| ▸ | STK10 | O94804 | 1/20 | 0.63 |
| ▸ | FLT3 | P36888 | 1/20 | 0.63 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.63 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.63 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.63 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.63 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.63 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.62 |
| ▸ | FLT1 | P17948 | 1/20 | 0.62 |
| ▸ | CDK2 | P24941 | 1/20 | 0.62 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.62 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7076160 | 0.83 | RET (1.00) | RETKDRKIF5BEGFRFLT1 | |
| SCHEMBL5864594 | 0.81 | RET (1.00) | RETKDRKIF5BEGFRFGFR1 | |
| SCHEMBL16760418 | 0.80 | RET (1.00) | RETKDRKIF5BEGFRFGFR1 | |
| SCHEMBL16785515 | 0.80 | RET (1.00) | RETKDRKIF5BEGFRFGFR1 | |
| SCHEMBL8976704 | 0.80 | EGFR (1.00) | RETKDREGFRRIPK2FLT1 | |
| SCHEMBL16760370 | 0.79 | RET (1.00) | RETKDRKIF5BEGFRFGFR1 | |
| SCHEMBL8522595 | 0.79 | RET (0.71) | RETKDRKIF5BEGFRJAK3 | |
| SCHEMBL16760410 | 0.79 | RET (1.00) | RETKDRKIF5BEGFRFGFR1 | |
| Hydrochloric Acid SCHEMBL16760376 | 0.79 | RET (0.98) | RETKDRKIF5BEGFRFGFR1 | |
| Hydrochloric Acid SCHEMBL16760380 | 0.78 | RET (0.98) | RETKDRKIF5BEGFRJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6638939-B2 | Anticancer agents | PARKER HUGHES INSTITUTE | 2003-10-28 | — | — | US | disclosed |