Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 1.00 |
| ▸ | KDR | P35968 | 4/20 | 0.66 |
| ▸ | RET | P07949 | 3/20 | 0.66 |
| ▸ | LCK | P06239 | 3/20 | 0.64 |
| ▸ | KRAS | P01116 | 1/20 | 0.61 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.61 |
| ▸ | FLT1 | P17948 | 1/20 | 0.60 |
| ▸ | CLK1 | P49759 | 1/20 | 0.59 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.59 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.58 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | SRC | P12931 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6180170 | 0.85 | EGFR (0.76) | EGFRKDRRETLCKFLT1 | |
| Hydrochloric Acid SCHEMBL6180124 | 0.84 | EGFR (0.74) | EGFRKDRRETLCKFLT1 | |
| SCHEMBL8976474 | 0.80 | EGFR (0.66) | EGFRKDRRETFLT1 | |
| SCHEMBL1257431 | 0.80 | EGFR (1.00) | EGFRKDRRETLCKFLT1 | |
| SCHEMBL29515328 | 0.80 | EGFR (1.00) | EGFRKDRRETLCKFLT1 | |
| SCHEMBL6181200 | 0.80 | EGFR (0.74) | EGFRKDRRETLCKFLT1 | |
| SCHEMBL7120134 | 0.80 | RET (0.71) | EGFRKDRRETLCKFLT1 | |
| Hydrochloric Acid SCHEMBL5475737 | 0.79 | EGFR (1.00) | EGFRKDRRETLCKRIPK2 | |
| Hydrochloric Acid SCHEMBL6180787 | 0.79 | EGFR (0.74) | EGFRKDRRETLCKCLK1 | |
| SCHEMBL8976742 | 0.79 | EGFR (0.74) | EGFRKDRRETLCKFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580870-A | ANTICARCINOGENIC AGENTS | ZENECA LIMITED (GB) | 1996-12-03 | — | — | US | disclosed |
| EP-0602851-B1 | Quinazoline derivatives | ZENECA LTD (GB) | 1996-10-09 | — | — | EP | disclosed |
| EP-0602851-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1994-06-22 | — | — | EP | disclosed |