Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 6/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5411201 | 0.91 | MC4R (0.66) | MC4RCYP3A4GPR119STSCYP3A5 | |
| SCHEMBL5413894 | 0.87 | MC4R (0.55) | MC4RCYP3A4GPR119CYP3A5 | |
| SCHEMBL14593411 | 0.87 | MC4R (0.52) | MC4RCYP3A4GPR119CYP3A5 | |
| SCHEMBL14593357 | 0.86 | MC4R (0.54) | MC4RCYP3A4GPR119STSCYP3A5 | |
| SCHEMBL5413683 | 0.86 | MC4R (0.54) | MC4RCYP3A4GPR119STSCYP3A5 | |
| SCHEMBL5418046 | 0.85 | MC4R (0.69) | MC4RCYP3A4GPR119STSCYP3A5 | |
| SCHEMBL5407759 | 0.84 | MC4R (0.49) | MC4RCYP3A4GPR119CYP3A5 | |
| SCHEMBL14593432 | 0.84 | MC4R (0.71) | MC4RCYP3A4CYP2C19GPR119LMNA | |
| SCHEMBL14593453 | 0.83 | MC4R (0.48) | MC4RCYP3A4GPR119CYP3A5 | |
| SCHEMBL14593286 | 0.83 | MC4R (0.59) | MC4RGPR119LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358163-A1 | MELANOCORTIN RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002059095-A1 | MELANOCORTIN RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2002-08-01 | — | — | WO | disclosed |