Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 14/20 | 0.80 |
| ▸ | GAK | O14976 | 1/20 | 0.72 |
| ▸ | STK16 | O75716 | 1/20 | 0.72 |
| ▸ | PIM1 | P11309 | 1/20 | 0.72 |
| ▸ | AXL | P30530 | 1/20 | 0.72 |
| ▸ | NEK2 | P51955 | 1/20 | 0.72 |
| ▸ | STK3 | Q13188 | 1/20 | 0.72 |
| ▸ | STK11 | Q15831 | 1/20 | 0.72 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.72 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.72 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.62 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | ITK | Q08881 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7113082 | 0.88 | AAK1 (0.84) | AAK1GAKSTK16PIM1AXL | |
| SCHEMBL7119108 | 0.87 | AAK1 (0.75) | AAK1GAKSTK16PIM1AXL | |
| SCHEMBL7112349 | 0.87 | AAK1 (1.00) | AAK1GAKSTK16PIM1AXL | |
| SCHEMBL7115610 | 0.87 | AAK1 (0.82) | AAK1GAKSTK16PIM1AXL | |
| SCHEMBL7120086 | 0.86 | AAK1 (0.80) | AAK1GAKSTK16PIM1AXL | |
| SCHEMBL7119909 | 0.86 | AAK1 (1.00) | AAK1GAKSTK16PIM1AXL | |
| SCHEMBL7120496 | 0.85 | AAK1 (0.79) | AAK1GAKSTK16PIM1AXL | |
| SCHEMBL7119102 | 0.84 | AAK1 (0.82) | AAK1GAKSTK16PIM1AXL | |
| SCHEMBL7113762 | 0.84 | AAK1 (0.77) | AAK1GAKSTK16PIM1AXL | |
| SCHEMBL19385563 | 0.84 | AAK1 (1.00) | AAK1GAKSTK16PIM1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028724-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | claimed |
| WO-2003028724-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |