Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6357046 | 1.00 | SLC6A3 (0.57) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL6358602 | 0.88 | SLC6A3 (0.63) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL7130274 | 0.88 | SLC6A3 (0.63) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL6357049 | 0.84 | SLC6A3 (0.60) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL6357051 | 0.84 | SLC6A3 (0.60) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL6363204 | 0.84 | SLC6A3 (0.60) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL6359095 | 0.84 | SLC6A3 (0.60) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL7036780 | 0.84 | SLC6A3 (0.60) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL8171321 | 0.83 | SLC6A3 (0.38) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL7036436 | 0.83 | SLC6A3 (0.38) | SLC6A3SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670375-B2 | Particularly, 8-aza-, 8-carbo- and 8-oxo- tropanes having 6-or 7-substituents; preferred are the dopamine transporter, the serotonin transporter and the norepinephrine transporter. | ORGANIX, INC. | 2003-12-30 | — | — | US | claimed |