Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.60 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | NR1I3 | Q14994 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.43 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.43 |
| ▸ | ALB | P02768 | 1/20 | 0.43 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6036587 | 0.94 | TTR (0.69) | TTRLMNAUSP2CYP2C9TBXA2R | |
| SCHEMBL6036194 | 0.89 | TTR (0.60) | TTRLMNAUSP2CYP2C9TBXA2R | |
| SCHEMBL1031824 | 0.88 | PTGS2 (0.76) | TTRPTGS2CAMK2AABCB11PTGS1 | |
| SCHEMBL6036173 | 0.88 | PTGS2 (0.52) | TTRLMNAUSP2CYP2C9TBXA2R | |
| SCHEMBL6036162 | 0.83 | PTGS2 (0.76) | TTRLMNAUSP2CYP2C9TBXA2R | |
| SCHEMBL6036623 | 0.81 | PTGS2 (0.72) | TTRLMNAUSP2CYP2C9TBXA2R | |
| SCHEMBL6036435 | 0.81 | KMT2A (0.49) | TTRLMNAUSP2CYP2C9TBXA2R | |
| SCHEMBL6036157 | 0.81 | USP2 (0.49) | TTRLMNAUSP2CYP2C9TBXA2R | |
| SCHEMBL23691079 | 0.80 | TTR (0.76) | TTRLMNAUSP2CYP2C9TBXA2R | |
| SCHEMBL6036430 | 0.79 | USP2 (0.46) | TTRLMNAUSP2CYP2C9TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1007505-B1 | CERTAIN 5-ALKYL-2-ARYLAMINOPHENYLACETIC ACIDS AND DERIVATIVES | NOVARTIS AG (CH) | 2003-04-16 | — | — | EP | claimed |