Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 3/20 | 0.71 |
| ▸ | DRD4 | P21917 | 3/20 | 0.71 |
| ▸ | DRD5 | P21918 | 3/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | MAOB | P27338 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 3/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997049 | 0.87 | DRD1 (0.72) | DRD1DRD4DRD5KDM4EPOLB | |
| SCHEMBL6935354 | 0.85 | DRD1 (0.71) | DRD1DRD4DRD5KDM4EPOLB | |
| SCHEMBL240294 | 0.85 | DRD1 (0.71) | DRD1DRD4DRD5KDM4EPOLB | |
| SCHEMBL110986 | 0.85 | DRD1 (0.71) | DRD1DRD4DRD5KDM4EPOLB | |
| Hydrochloric Acid SCHEMBL14966707 | 0.84 | DRD1 (0.69) | DRD1DRD4DRD5KDM4EPOLB | |
| Hydrochloric Acid SCHEMBL7114617 | 0.84 | DRD1 (0.69) | DRD1DRD4DRD5KDM4EPOLB | |
| SCHEMBL6689247 | 0.83 | DRD1 (0.68) | DRD1DRD4DRD5KDM4EPOLB | |
| SCHEMBL7091880 | 0.83 | DRD1 (0.67) | DRD1DRD4DRD5KDM4EPOLB | |
| SCHEMBL14396561 | 0.82 | POLB (0.63) | DRD1DRD4DRD5KDM4EPOLB | |
| SCHEMBL10190886 | 0.82 | DRD1 (0.66) | DRD1DRD4DRD5KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599902-B2 | For treating or preventing a protein kinase related disorder | SUGEN, INC. | 2003-07-29 | — | — | US | disclosed |
| US-20030125370-A1 | 5-ARALKYSUFONYL-3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS | SUGEN, INC. | 2003-07-03 | — | — | US | disclosed |
| WO-2002096361-A2 | 5-ARALKYLSULFONYL-3- (PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS | SUGEN, INC. (US) | 2002-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030125370-A1 | 5-ARALKYSUFONYL-3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS | DMPK, ADK, MAP3K20 | DRD1 4738/4885DRD4 4659/4885DRD5 4001/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.