SCHEMBL7123630

SCHEMBL7123630

C[SiH](C)OC[C@@]1(C(C)(C)C)CC(=O)CN1C(=O)OC(C)(C)C

nearest known ligand 0.32

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
DDB1 Q16531 2/20 0.32
CRBN Q96SW2 2/20 0.32
BUB1 O43683 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4698979 0.74 NR1H2 (0.36)
SCHEMBL21244820 0.72 BUB1 (0.40) DDB1CRBNBUB1
SCHEMBL26915659 0.72 GRIN2B (0.38) DDB1CRBNBUB1
SCHEMBL28036996 0.72
SCHEMBL751694 0.71 BUB1 (0.35) DDB1CRBNBUB1
SCHEMBL25301908 0.69 BUB1 (0.38) DDB1CRBNBUB1
SCHEMBL350967 0.69 BUB1 (0.38) DDB1CRBNBUB1
SCHEMBL31456782 0.69 BUB1 (0.38) DDB1CRBNBUB1
SCHEMBL17937395 0.67 BUB1 (0.36) DDB1CRBNBUB1
SCHEMBL26915679 0.67 BUB1 (0.36) DDB1CRBNBUB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030216374-A1 Antibiotic oxazolidinone derivatives SYNGENTA LIMITED (GB) 2003-11-20 US disclosed
US-6605630-B1 Active against drug resistant gram positive pathogens SYNGENTA LIMITED (GB) 2003-08-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030216374-A1 Antibiotic oxazolidinone derivatives OXA1L, HRH1, OGDH DDB1 2801/4885CRBN 1203/4885BUB1 1312/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.