Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2681006 | 0.86 | PDE5A (0.57) | PDE5AALDH1A1HPGDIKBKBKIT | |
| SCHEMBL299952 | 0.85 | PDE5A (0.56) | PDE5AALDH1A1HPGDIKBKBKIT | |
| SCHEMBL291345 | 0.83 | PDE5A (0.62) | PDE5AALDH1A1HPGDIKBKBKIT | |
| SCHEMBL20559620 | 0.81 | PDE5A (0.76) | PDE5AALDH1A1HPGDIKBKBLMNA | |
| SCHEMBL291289 | 0.79 | PDE5A (0.48) | PDE5AALDH1A1KITFLT3DHODH | |
| SCHEMBL291323 | 0.78 | PDE5A (0.56) | PDE5AALDH1A1KITFLT3LMNA | |
| SCHEMBL290507 | 0.77 | PDE5A (0.67) | PDE5AALDH1A1KITFLT3 | |
| SCHEMBL27950966 | 0.77 | PDE5A (0.69) | PDE5AALDH1A1HPGDIKBKBLMNA | |
| SCHEMBL26647638 | 0.77 | PDE5A (0.57) | PDE5AALDH1A1HPGDLMNATSHR | |
| SCHEMBL27950945 | 0.77 | PDE5A (0.57) | PDE5AALDH1A1HPGDIKBKBFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030104974-A1 | Dual inhibitorsof PDE 7 and PDE 4 | BRISTOL-MYERS SQUIBB COMPANY | 2003-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030104974-A1 | Dual inhibitorsof PDE 7 and PDE 4 | PDE4A, PDE4B, PDE7B | PDE5A 15/4885ALDH1A1 1814/4885HPGD 2653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.