Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.65 |
| ▸ | PRKAA1 | Q13131 | 12/20 | 0.65 |
| ▸ | PRKAA2 | P54646 | 10/20 | 0.65 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.65 |
| ▸ | FLT3 | P36888 | 4/20 | 0.65 |
| ▸ | EGFR | P00533 | 3/20 | 0.65 |
| ▸ | GRK5 | P34947 | 3/20 | 0.65 |
| ▸ | PLK4 | O00444 | 2/20 | 0.65 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.65 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.65 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.65 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.65 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.65 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.65 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.65 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.65 |
| ▸ | INSR | P06213 | 2/20 | 0.65 |
| ▸ | LCK | P06239 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL143725 | 0.93 | KDR (0.65) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL142711 | 0.93 | KDR (0.71) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL142827 | 0.92 | PRKAA1 (0.69) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL145122 | 0.92 | PRKAA1 (0.67) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL144201 | 0.91 | KDR (0.74) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL144887 | 0.91 | KDR (0.74) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL144305 | 0.91 | KDR (0.74) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL143925 | 0.90 | KDR (0.65) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL140217 | 0.90 | KDR (0.75) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL146648 | 0.89 | PRKAA1 (0.75) | KDRPRKAA1PRKAA2PDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599902-B2 | For treating or preventing a protein kinase related disorder | SUGEN, INC. | 2003-07-29 | — | — | US | disclosed |
| US-20030125370-A1 | 5-ARALKYSUFONYL-3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS | SUGEN, INC. | 2003-07-03 | — | — | US | disclosed |
| WO-2002096361-A2 | 5-ARALKYLSULFONYL-3- (PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS | SUGEN, INC. (US) | 2002-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030125370-A1 | 5-ARALKYSUFONYL-3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS | DMPK, ADK, MAP3K20 | KDR 398/4885PRKAA1 116/4885PRKAA2 138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.