Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | STK4 | Q13043 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 10/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 10/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 10/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 7/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | KIF5B | P33176 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7124603 | 0.85 | EGFR (0.44) | EGFRALDH1A1STK4KMT2AHDAC1 | |
| SCHEMBL8488612 | 0.85 | EGFR (0.51) | EGFRHDAC1HDAC8HDAC6HDAC3 | |
| SCHEMBL8155324 | 0.79 | EGFR (0.55) | EGFRHDAC1HDAC8HDAC6HDAC3 | |
| SCHEMBL7235690 | 0.77 | EGFR (0.55) | EGFR | |
| SCHEMBL7121754 | 0.76 | EGFR (0.54) | EGFRKDRRET | |
| SCHEMBL7125721 | 0.74 | EGFR (0.70) | EGFRKDR | |
| SCHEMBL7238302 | 0.69 | EGFR (0.47) | EGFRHDAC1HDAC8HDAC6HDAC3 | |
| SCHEMBL7244428 | 0.69 | EGFR (0.48) | EGFRHDAC1HDAC8HDAC6HDAC3 | |
| SCHEMBL7242679 | 0.66 | EGFR (0.74) | EGFRKDR | |
| SCHEMBL8976335 | 0.66 | RET (0.65) | EGFRKDRRETKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030087881-A1 | Irreversible inhibitors of tyrosine kinases | BRIDGES ALEXANDER JAMES (US) | 2003-05-08 | — | — | US | claimed |
| US-6153617-A | Irreversible bicyclic inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | claimed |
| US-20030087881-A1 | Irreversible inhibitors of tyrosine kinases | BRIDGES ALEXANDER JAMES (US) | 2003-05-08 | — | — | US | disclosed |
| US-6153617-A | Irreversible bicyclic inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087881-A1 | Irreversible inhibitors of tyrosine kinases | ERBB2, ERBB3, LCK | EGFR 26/4885ALDH1A1 2889/4885STK4 131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.