Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.55 |
| ▸ | ERBB4 | Q15303 | 4/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.50 |
| ▸ | ROS1 | P08922 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8155324 | 0.91 | EGFR (0.55) | EGFRERBB2ERBB4AURKB | |
| SCHEMBL8489385 | 0.85 | EGFR (0.57) | EGFRERBB2ERBB4CHEK2ROS1 | |
| SCHEMBL7243958 | 0.84 | EGFR (0.71) | EGFRERBB2ERBB4 | |
| SCHEMBL7235693 | 0.84 | EGFR (0.54) | EGFRERBB2ERBB4CHEK2ROS1 | |
| SCHEMBL7235485 | 0.82 | EGFR (0.62) | EGFRERBB2AURKB | |
| SCHEMBL7121754 | 0.81 | EGFR (0.54) | EGFRERBB2 | |
| SCHEMBL7238302 | 0.77 | EGFR (0.47) | EGFRERBB2 | |
| SCHEMBL7233723 | 0.77 | EGFR (0.70) | EGFRERBB2ERBB4CHEK2ROS1 | |
| SCHEMBL7241721 | 0.77 | EGFR (0.64) | EGFRERBB2ERBB4CHEK2ROS1 | |
| SCHEMBL7124614 | 0.77 | EGFR (0.44) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127374-A | AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-03 | — | — | US | claimed |
| US-6562818-B1 | For treating cancer, atherosclerosis, restenosis, endometriosis, and psoriasis | WARNER-LAMBERT COMPANY | 2003-05-13 | — | — | US | disclosed |
| US-6127374-A | AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-03 | — | — | US | disclosed |